ESTROGEN RECEPTOR-D5 ANTIBODY IS AN INDEPENDENT NEGATIVE PROGNOSTIC FACTOR IN GASTRIC-CANCER
ESTROGEN RECEPTOR-D5 ANTIBODY IS AN INDEPENDENT NEGATIVE PROGNOSTIC FACTOR IN GASTRIC-CANCER
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DOI：
10.1002/bjs.1800780321
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发表时间：
1991-03-01
影响因子：
9.6
通讯作者：
MORRIS, DL
中科院分区：
文献类型：
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作者：
HARRISON, JD;JONES, JA;MORRIS, DL
最近的研究表明，除那些被认为对性激素有反应的组织外，例如胃癌中也存在雌激素受体。 体外实验表明雌二醇对胃癌细胞系有营养作用。 因此，我们在 188 名接受胃癌手术的连续患者中研究了 D5（一种雌激素受体相关蛋白）状态对生存的影响。 92 名患者（49%）的 D5 抗体呈阳性。 D5 阳性组和 D5 阴性组之间在年龄或不良预后特征（例如高级别肿瘤或晚期）方面没有差异。 D5阴性患者比D5阳性患者具有显着的生存优势。 D5 阴性肿瘤患者的生存期 95% 置信区间为 63-101 周，而 D5 阳性肿瘤患者的生存期为 39-66 周（Mantel-Cox 统计 = 4.15，P = 0.042）。 Cox 比例风险模型的预后因素分析显示，肿瘤分期 (P = 0.001) 和 D5 状态 (P = 0.003) 是胃癌的重要独立因素。 劳伦的类型、年级和性别在本次小编的调查中并不是显着的独立因素。
Recent studies have demonstrated oestrogen receptors in tissues other than those considered to be sex hormone responsive, for instance in gastric cancer. In vitro experiments have shown oestradiol to be trophic to gastric cancer cell lines. The effect of D5 (an oestrogen receptor-related protein) status on survival was therefore studied in a group of 188 consecutive patients undergoing surgery for gastric cancer. Ninety-two patients (49 per cent) were positive for the D5 antibody. There were no differences between the D5-positive and D5-negative groups for age or adverse prognostic features such as high grade tumours or advanced stage. The D5-negative patients had a significant survival advantage over the D5-positive patients. The 95 per cent confidence interval for survival in the patients with D5-negative tumours was 63-101 weeks compared with 39-66 weeks for the patients with D5-positive tumours (Mantel-Cox statistic = 4.15, P = 0.042). Prognostic factor analysis with a Cox proportional hazards model showed tumour stage (P = 0.001) and D5 status (P = 0.003) to be significant independent factors in gastric cancer. Lauren type, grade and gender were not significant independent factors in this small series.