Amphiphilic polyphosphazenes as membrane materials: influence of side group on radiation cross-linking.
Amphiphilic polyphosphazenes as membrane materials: influence of side group on radiation cross-linking.
复制标题
两亲性聚磷腈作为膜材料：侧基对辐射交联的影响。
DOI：
10.1016/0142-9612(88)90045-2
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发表时间：
1988
期刊：
影响因子：
14
通讯作者：
Neenan,TX
中科院分区：
文献类型：
--
作者：
Allcock,HR;Gebura,M;Kwon,S;Neenan,TX
用三氟醚或苯氧化合物与甲胺依次取代[NPCI2] n中的氯，制备了两亲性混合取代基多磷腈[NP(OCH2CF3)x(NHCH3)y] n和[NP(OC6H5)x(NHCH3)y]n。这些物种的薄膜通过暴露于γ辐射交联，并监测所得膜的半透性。并与单取代基聚合物[NP(OCH2CF3)z]n、[NP(OC6,H5)2]n和[NP(NHCH3)2]n的辐射诱导交联和成膜性能进行了比较。辐射交联过程似乎涉及甲基胺取代基甲基上的自由基反应。讨论了这些材料在生物医学研究中的应用前景。
The amphiphilic mixed-substituent polyphosphazenes, [NP(OCH2CF3)x(NHCH3)y]nand [NP(OC6H5)x(NHCH3)y]n, have been prepared by the sequential replacement of chlorine in [NPCI2]nby trifluoroethoxide or phenoxide and methylamine. Thin films of these species were cross-linked by exposure to γ radiation and the semipermeability of the resultant membranes was monitored. The radiation-induced cross-linking and membrane-forming properties of these polymers were compared with those of the single substituent polymers, [NP(OCH2CF3)z]n, [NP(OC6,H5)2]n, and [NP(NHCH3)2]n. The radiation-cross-linking process appeared to involve free radical reactions at the methyl groups of the methylamino substituants. The possible utility of these materials in biomedical research is discussed.