Vitamin D and muscle strength in patients with previous fractures.
Vitamin D and muscle strength in patients with previous fractures.
复制标题
既往骨折患者的维生素 D 和肌肉力量。
DOI：
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
J. Tapper
中科院分区：
文献类型：
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作者：
C. Inderjeeth;D. Glennon;A. Petta;J. Soderstrom;Irene Boyatzis;J. Tapper
目的
旨在评估西澳大利亚州一家三级医院出院的长骨骨折患者的维生素 D 状态及其与客观左腿肌肉力量测量的关系。第二个目标是确定平衡和功能状态测试是否是肌肉力量的有效预测因子，以及它们是否与血清 25 羟基维生素 D (25OHD) 水平相关。
方法
这是一项横断面研究。邀请在 12 个月内因低冲击性骨折从三级医院出院的患者参加。邀请是通过对骨质疏松症风险和治疗进行邮政调查审核并请求参与该研究。 60岁以上的女性也被纳入其中。同意参加的患者被邀请参加研究诊所。患者接受了人口统计数据、肌肉力量、功能评估和生化参数（包括评估的血清 25OHD）。
结果
在完成研究的 99 名受试者中，平均 25OHD 水平为 52.0 nmol/L。与 25OHD 的主要单变量关联是认知功能、功能指数、阳光照射、白蛋白和甲状旁腺激素 (PTH)。在多变量模型中，最强且最显着的关联是肌肉力量与 25OHD 水平之间的关系（r=0.489，p<0.001）。肌肉力量与 >50 nmol/L 的 25OHD 水平密切相关（r=0.51，p<0.001）。
结论
这项研究表明 25OHD 水平与左腿肌肉力量之间存在显着关联。这种独立的关联支持了这样的假设：25OHD 缺乏可能是导致肌肉力量较差的原因。
AIM
To assess the vitamin D status and its association with objective left leg muscle strength measurements in patients with long-bone fracture discharged from a tertiary hospital in Western Australia. The secondary objective was to determine whether tests of balance and functional status are valid predictors of muscle strength and if they correlate with serum 25 hydroxyvitamin D (25OHD) levels.
METHODS
This was a cross sectional study. Patients who had been discharged from a tertiary hospital following a low impact fracture over a 12-month period were invited to participate. Invitation was through a postal survey audit of osteoporosis risk and treatment and requesting participation in the study. Females over the age of 60 were included. Patients agreeing to participate were invited to attend a research clinic. Patients had demographic data, muscle strength, functional assessments, and biochemical parameters including serum 25OHD assessed.
RESULTS
Of the 99 subjects who completed the study, the mean 25OHD level was 52.0 nmol/L. The main univariate associations with 25OHD were cognitive function, functional indices, sun exposure, albumin, and parathyroid hormone (PTH). In a multivariate model,the strongest and most significant association was between muscle strength and 25OHD levels (r=0.489, p<0.001). Muscle strength was most strongly associated with 25OHD levels >50 nmol/L (r=0.51, p<0.001).
CONCLUSION
This study demonstrates a significant association between 25OHD levels and left leg muscle strength. This independent association supports the hypothesis that 25OHD deficiency may be responsible for poor muscle strength.
影响因子：
4.8
作者：
COSTA, EM;BLAU, HM;FELDMAN, D
通讯作者：
FELDMAN, D
DOI：
10.1093/geronj/45.6.p239
发表时间：
1990-11-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
TINETTI, ME;RICHMAN, D;POWELL, L
通讯作者：
POWELL, L