DOSE VOLUME HISTOGRAM ANALYSIS OF LIVER RADIATION TOLERANCE
DOSE VOLUME HISTOGRAM ANALYSIS OF LIVER RADIATION TOLERANCE
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DOI：
10.1016/0360-3016(86)90412-8
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发表时间：
1986-01-01
影响因子：
7
通讯作者：
KESSLER, M
中科院分区：
文献类型：
--
作者：
AUSTINSEYMOUR, MM;CHEN, GTY;KESSLER, M
11例胰腺癌或胆道系统癌患者在Lawrence Berkeley实验室[美国]接受了重带电粒子放射治疗和全肝重带电粒子放射治疗。整个肝脏的剂量范围为10至24戈瑞当量（10至24戈瑞的低LET光子辐射的生物当量），而原发性病变的剂量范围为53.5至70戈瑞当量（GyE）。级分大小为2至3 GyE。肝脏接受部分以及整个器官照射。在所有11例患者中获得了肝脏的积分剂量体积直方图。积分剂量体积直方图在纵坐标上显示了超过横坐标上指定剂量照射的肝脏百分比。在这项研究中，这些患者的临床肝脏辐射耐受性与积分剂量体积直方图中包含的信息相关。1例患者发生放射性肝炎。该患者的积分剂量体积直方图不同于其他10例患者的剂量体积直方图。这种差异在30至40 Gy剂量范围内最大。我们的研究结果表明，超过30至35 GyE的肝脏剂量应限制在30%的肝脏或更少时，18 GyE的全肝辐射提供在2 GyE每部分除了胰腺或胆道系统的初级辐射。
Eleven patients with carcinoma of the pancreas or biliary system received heavy charged particle radiation treatments and whole liver heavy charged particle radiation at Lawrence Berkeley Laboratory [USA]. Doses to the whole liver ranged from 10 to 24 Gray-equivalent (the biological equivalent of 10 to 24 Gray of low-LET photon radiation), whereas the dose to the primary lesion ranged from 53.5 to 70 Gray-equivalent (GyE). The fraction size was 2 to 3 GyE. The liver received partial as well as whole organ irradiation. Integral dose volume histograms for the liver were obtained in all 11 patients. An integral dose volume histogram displays on the ordinate the percentage of liver that was irradiated in excess of the dose specified on the abscissa. In this study, the clinical liver radiation tolerance of these patients is correlated with the information contained in an integral dose volume histogram. One patient developed radiation hepatitis. The integral dose volume histogram of this patient differed from the dose volume histograms of the other 10 patients. This difference was greatest in the range of doses between 30 and 40 GyE. Our results suggest that liver doses in excess of 30 to 35 GyE should be limited to 30% of the liver or less when 18 GyE of whole liver radiation is delivered at 2 GyE per fraction in addition to primary radiation of the pancreas or biliary system.