Performance evaluation of a dedicated camera suitable for dynamic radiopharmaceuticals evaluation in small animals
Performance evaluation of a dedicated camera suitable for dynamic radiopharmaceuticals evaluation in small animals
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DOI：
10.1109/tns.2007.896212
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发表时间：
2007-06-01
影响因子：
1.8
通讯作者：
Varvarigou, Alexandra
中科院分区：
文献类型：
--
作者：
Loudos, George;Majewski, Stan;Varvarigou, Alexandra
作为托马斯杰斐逊国家加速器设施（美国）的探测器和成像组与N.C.S.R.放射性同位素和放射诊断产品研究所（iRRP）合作的结果，“Demokritos”和雅典国立技术大学（希腊）的生物医学模拟和成像应用实验室（BIOSIM）开发了一种针对Tc-99 m成像优化的小鼠大小的相机。探测器在杰斐逊实验室制造，并转移到希腊，在那里用幻影和小动物进行评估。该系统最初将用于小动物的平面动态研究，以评估新的放射性标记的生物分子在肿瘤学研究中的性能。探测器的有效面积约为4.8 mm x 96 mm。它基于两个平板Hamamatsu H8500位置敏感光电倍增管（PSPMT）、像素化NaI（TI）闪烁体和高分辨率铅平行孔准直器。该系统的开发，以优化灵敏度和分辨率的小动物体内注射锝化合物成像。在平面模式与phantomy系统评估的结果报告。本文给出了用> 100 μ Ci的两种常规和新型放射性药物，即Tc-99 m-MDP和Tc-99 m-Bombesin注射的小鼠的体内动态研究结果。
As the result of a collaboration between the Detector and Imaging Group of Thomas Jefferson National Accelerator Facility (US), the Institute of Radioisotopes and Radiodiagnostic Products (iRRP) of N.C.S.R. "Demokritos" and the Biomedical Simulations and Imaging Applications Laboratory (BIOSIM) of National Technical University of Athens (Greece), a mouse sized camera optimized for Tc-99m imaging was developed. The detector was built in Jefferson Lab and transferred to Greece, where it was evaluated with phantoms and small animals. The system will be used initially for planar dynamic studies in small animals, in order to assess the performance of new radiolabeled biomolecules for oncological studies. The active area of the detector is approximately 4.8 mm x 96 mm. It is based on two flat-panel Hamamatsu H8500 position sensitive photomultiplier tubes (PSPMT), a pixelated Nal(TI) scintillator and a high resolution lead parallel-hole collimator. The system was developed to optimize both sensitivity and resolution for in vivo imaging of small animals injected with technetium compounds. The results of system evaluation in planar mode with phantoms are reported. Results are presented for in* vivo dynamic studies of mice injected with > 100 mu Ci of two conventional and novel radiopharmaceuticals, namely Tc-99m -MDP and Tc-99m-Bombesin.