CHEMICAL SPLANCHNICECTOMY IN PATIENTS WITH UNRESECTABLE PANCREATIC-CANCER - A PROSPECTIVE RANDOMIZED TRIAL
CHEMICAL SPLANCHNICECTOMY IN PATIENTS WITH UNRESECTABLE PANCREATIC-CANCER - A PROSPECTIVE RANDOMIZED TRIAL
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DOI：
10.1097/00000658-199305010-00004
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发表时间：
1993-05-01
影响因子：
9
通讯作者：
ALDRETE, JS
中科院分区：
文献类型：
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作者：
LILLEMOE, KD;CAMERON, JL;ALDRETE, JS
目的：完成一项前瞻性、随机、双盲研究，比较在组织学上证实不可切除的胰腺癌患者术中使用50%酒精的化学内脏切除术与注射生理盐水的安慰剂。方法术前和术后2个月对患者进行疼痛、情绪和疼痛所致残疾的标准化评估。65名患者接受了酒精化学内脏切除术，而72名患者接受了安慰剂。两组患者在年龄、性别、位置、肿瘤分期、手术情况、术后化疗和放疗的使用、疼痛、情绪和残疾的初步评估评分等方面相似。结果两组在住院死亡率、并发症、恢复口服摄入或住院时间方面均无差异。酒精组在随访2个月、4个月和6个月以及最终评估时的平均疼痛评分明显较低(p
Objective A prospective, randomized, double-blind study was completed comparing intraoperative chemical splanchnicectomy with 50% alcohol versus a placebo injection of saline in patients with histologically proven unresectable pancreatic cancer.Methods Standardized assessment of pain, mood, and disability due to pain was completed, preoperatively and at 2-month intervals until death. Chemical splanchnicectomy with alcohol was performed in 65 patients, whereas 72 patients received the placebo. The two groups were similar with respect to age, sex, location, and stage of tumor, operation performed, the use of postoperative chemo- and radiation therapy, and initial assessment scores for pain, mood, and disability.Results No differences in hospital mortality or complications, return to oral intake, or length of hospital stay were observed. Mean pain scores were significantly lower in the alcohol group at 2-, 4-, and 6-month follow-up and at the final assessment (p