EFFECTS OF SPACEFLIGHT ON TRABECULAR BONE IN RATS
EFFECTS OF SPACEFLIGHT ON TRABECULAR BONE IN RATS
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DOI：
10.1152/ajpregu.1983.244.3.r310
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发表时间：
1983-01-01
影响因子：
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通讯作者：
KIMMEL, DB
中科院分区：
文献类型：
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作者：
JEE, WSS;WRONSKI, TJ;KIMMEL, DB
在COSMOS 1129生物卫星上进行18.5天的轨道飞行后，观察到雄性Wistar大鼠骨小梁的变化。太空飞行导致矿化组织减少，胫骨和肱骨近端骨髓脂肪含量增加。在生长软骨-干骺端交界处附近，成骨细胞数量立即下降，但破骨细胞数量不变。显然，在太空飞行期间，骨骼的形成可能受到抑制，但吸收仍然保持不变。除胫骨近端骨小梁外，观察到的骨骼变化在飞行后29天内恢复正常。
Alterations in trabecular bone were observed in growing male Wistar rats after 18.5 days of orbital flight on the COSMOS 1129 biosatellite. Spaceflight induced a decreased mass of mineralized tissue and an increased fat content of the bone marrow in the proximal tibial and humeral metaphyses. The osteoblast population appeared to decline immediately adjacent to the growth cartilage-metaphyseal junction, but osteoclast numbers were unchanged. Apparently, bone formation may have been inhibited during spaceflight, but resorption remained constant. With the exception of trabecular bone mass in the proximal tibia, the observed skeletal changes returned to normal during a 29-day postflight period.