Ventral hippocampal neurons are shaped by experience to represent behaviorally relevant contexts.
Ventral hippocampal neurons are shaped by experience to represent behaviorally relevant contexts.
复制标题
DOI：
10.1523/jneurosci.5458-12.2013
复制
发表时间：
2013-05-01
期刊：
影响因子：
--
通讯作者：
Eichenbaum H
中科院分区：
文献类型：
--
作者：
Komorowski RW;Garcia CG;Wilson A;Hattori S;Howard MW;Eichenbaum H
记忆可以在不同的分辨率水平上被回忆起来，从单一经历中具体事件的详细再现到多个相关经历的广泛概括。在这里，我们提供的证据表明，反映记忆的特异性或一般性的神经表征沿着大鼠海马区CA3区的背腹轴存在差异。在背侧CA3，神经元迅速将事件的身份与特定位置联系起来，而在更腹侧的CA3区域，神经元通过延长训练逐渐积累信息，形成概括空间背景内相关事件的表征，并区分不同背景下的事件。
Memories can be recalled at different levels of resolution, from a detailed rendition of specific events within a single experience to a broad generalization across multiple related experiences. Here we provide evidence that neural representations reflecting the specificity or generality of memories are differentially represented along the dorsal-ventral axis of the CA3 area of the rat hippocampus. In dorsal CA3, neurons rapidly associate the identity of events with specific locations whereas, in more ventrally located CA3 regions, neurons gradually accumulate information across extended training to form representations that generalize across related events within a spatial context and distinguish events across contexts.