Gender difference in age at onset of schizophrenia: a cross sectional study from Pakistan.
Gender difference in age at onset of schizophrenia: a cross sectional study from Pakistan.
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发表时间：
2010-10
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通讯作者：
I. Naqvi;M. Murtaza;M. R. Nazir;H. Naqvi
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作者：
I. Naqvi;M. Murtaza;M. R. Nazir;H. Naqvi
目的验证发展中国家性别对精神分裂症发病年龄的影响。方法采用结构化问卷对2002年至2008年巴基斯坦卡拉奇某三级保健医院252例符合DSM-IV诊断标准的精神分裂症患者的病历进行分析。发病年龄定义为出现精神病症状的年龄、第一次接触医疗保健提供者的年龄和第一次住院的年龄。使用描述性统计报告社会人口统计变量，并使用t检验比较不同性别的所有发病年龄指标。结果女性119例，男性133例，平均年龄37.6±12.8岁。所有三项衡量发病年龄的指标在女性和男性之间都没有差异。男性首次出现精神症状的平均年龄为24.86±8.83岁，女性为26.57±9.96岁，P=0.160。在指数住院治疗精神病时，男性的平均年龄为29.50±10.64岁，女性为31.61±12.07岁，P=0.164。男性首次接触照顾者的平均年龄为29.73±37.58岁(n=119)，女性为29.38±11.99岁(n=108)，p=0.926。结论我国人群中不同性别精神分裂症患者的发病年龄无显著差异。这证实了南亚人群中精神分裂症的流行病学差异。
OBJECTIVE To validate the effect of gender on age at onset of schizophrenia in a developing country. METHODS Medical records of 252 patients diagnosed with schizophrenia according to DSM-IV criteria at a tertiary care hospital in Karachi, Pakistan between 2002 and 2008 were reviewed using a structured questionnaire. Age at onset was defined as age at onset of psychotic symptoms, age at first contact with a health care provider and age at first hospitalization. Socio-demographic variables were reported using descriptive statistics and all measures of age at onset were compared across gender using t-test. RESULTS There were 119 women and 133 men with mean age of 37.6 +/- 12.8 years. All three measures of age at onset of illness showed no difference between women and men. The mean age when first psychotic symptoms appeared in men was 24.86 +/- 8.83 years (n = 128) while that in women was 26.57 +/- 9.96 years (n = 111), p = 0.160. The mean age at index hospitalization for treatment of psychosis in men was 29.50 +/- 10.64 years (n = 123) and in women was 31.61 +/- 12.07 years (n = 103), p = 0.164. The mean age at first contact with any caregiver in men was 29.73 +/- 37.58 years (n = 119) and in women was 29.38 +/- 11.99 years (n = 108), p = 0.926. CONCLUSION There is no significant difference in age at onset of schizophrenia across gender in our population. This validates a difference in epidemiology of schizophrenia in the South Asian population.