Mapping the valosin-containing protein (VCP) gene on human chromosome 9 and mouse chromosome 4, and a likely pseudogene on the mouse X chromosome.
Mapping the valosin-containing protein (VCP) gene on human chromosome 9 and mouse chromosome 4, and a likely pseudogene on the mouse X chromosome.
复制标题
绘制人类 9 号染色体和小鼠 4 号染色体上的缬洛辛蛋白 (VCP) 基因，以及小鼠 X 染色体上的一个可能的假基因。
DOI：
10.1007/s003359900566
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Fisher,EM
中科院分区：
文献类型：
--
作者：
Hoyle,J;Tan,KH;Fisher,EM
含缬氨肽蛋白基因（Vcp）的单链构象多态性变异体在F1小鼠与近交小家鼠回交后代中的分离表明，该基因定位在X染色体上的Xist位点附近。这个位置与人类基因的同源性是出乎意料的。进一步的调查使用的内含子序列从Vcpresulted在该内含子的映射到小鼠4号染色体，这是预期的位置与人类基因图谱的比较。这些结果的最可能的解释是，小鼠X染色体上有一个Vcp加工的假基因，而含有缬沙素的蛋白质是由4号染色体上的基因座编码的。
The segregation of a single-strand conformation polymorphism variant of the valosin-containing protein gene (Vcp) in backcrosses of F1mice to inbredMus spretusindicated that the gene mapped close to theXistlocus on the X-chromosome. This position was unexpected in relation to homologies with the gene in humans. Further investigation using an intron sequence fromVcpresulted in mapping of this intron to mouse chromosome 4, which was the position expected from comparison with the human gene map. The most probable explanation of these results is that the mouse X-chromosome has aVcp-processed pseudogene, and that the valosin-containing protein is encoded by the locus on chromosome 4.