Applications of superficially porous particles: High speed, high efficiency or both?
Applications of superficially porous particles: High speed, high efficiency or both?
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DOI：
10.1016/j.chroma.2011.07.083
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发表时间：
2012-03-09
影响因子：
4.1
通讯作者：
Long, William J.
中科院分区：
文献类型：
--
作者：
Wang, Xiaoli;Barber, William E.;Long, William J.
新一代的表面多孔颗粒（SPP）提供了令人印象深刻的色谱效率相比，完全多孔颗粒。具体地说，与亚2 μ m的完全多孔颗粒相比，现代亚3 μ m的SPP产生大大改进的降低的板高度，但背压较低。这一特性使它们对各种类型的应用具有吸引力，SPP正迅速被许多分析实验室采用。在这篇综述中，我们使用优化理论来比较现代SPP和全多孔颗粒在优化条件下的性能极限，以回答这个问题：现代SPP的最佳应用是什么？它们是最适合快速分离，还是高效分离，还是两者都适合？在不同的应用领域使用现代SPP的成功例子进行审查，在广泛的样品复杂性和分析时间。还讨论了使用这种颗粒的实际方面和未来的发展可能性。(C)2011 Elsevier B.V.保留所有权利。
The new generation of superficially porous particles (SPPs) offers impressive chromatographic efficiency compared to totally porous particles. Specifically, modern sub-3-mu m SPPs generate much improved reduced plate height but at lower backpressure compared to sub-2-mu m totally porous particles. This feature makes them attractive for various types of applications and SPPs are quickly being adopted in many analytical laboratories. In this review, we use optimization theory to compare the performance limit of modern SPPs and totally porous particles under optimized conditions, in order to answer the question: what are the optimal applications for modern SPPs? Are they most suitable for fast separations, or for high efficiency separations, or for both? Successful examples of using modern SPPs in different application areas are reviewed, over a wide range of sample complexity and analysis time. Practical aspects of the use of such particles and future development possibilities are also discussed. (C) 2011 Elsevier B.V. All rights reserved.