Adrenomedullin receptors: molecular identity and function
Adrenomedullin receptors: molecular identity and function
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DOI：
10.1016/s0196-9781(01)00532-0
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发表时间：
2001-11-01
期刊：
影响因子：
3
通讯作者：
Smith, DM
中科院分区：
文献类型：
--
作者：
Hay, DL;Smith, DM
自1993年被发现以来，肾上腺髓质素(AM)已经发表了600多篇文章。这种多功能多肽具有强大的血管扩张作用，最近来自AM基因缺失小鼠的证据表明，AM在血管发育中发挥着重要作用。然而，由于缺乏有效的AM受体克隆和非肽受体配体，阻碍了对这一重要多肽的研究进展。本文主要介绍降钙素受体样受体(CRLR)是AM及其相关血管活性多肽降钙素基因相关肽(CGRP)的受体这一命题。受体活性修饰蛋白(RAMP)是定义CRLR药理学必不可少的，也将被讨论。我们将描述AM受体是如何被报道信号和调控的，并考虑是否存在超越CRLR/RAMP组合的AM受体。(C)2001 Elsevier Science Inc.保留所有权利。
Since its discovery in 1993 adrenomedullin (AM) has been the subject over 600 published articles. This multifunctional peptide has powerful vasodilator actions and recent evidence from AM gene-deleted mice suggest that AM plays an essential role in vascular development. However the lack of valid AM receptor clones and non-peptide receptor ligands has considerably slowed research progress on this important peptide. In this review we have focused on the proposition that the calcitonin receptor-like receptor (CRLR) is a receptor both for AM and the related vasoactive peptide calcitonin gene-related peptide (CGRP). The receptor activity modifying proteins (RAMPS) that are essential for defining CRLR pharmacology will also be discussed. We will describe how AM receptors have been reported to signal and be regulated and to consider whether further receptors for AM beyond CRLR/RAMP combinations might exist. (C) 2001 Elsevier Science Inc. All rights reserved.