Factors Related to Coronary Heart Disease Risk Among Men: Validation of the Framingham Risk Score
Factors Related to Coronary Heart Disease Risk Among Men: Validation of the Framingham Risk Score
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DOI：
10.5888/pcd11.140045
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发表时间：
2014-08-01
影响因子：
5.5
通讯作者：
Hebert, James R.
中科院分区：
文献类型：
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作者：
Gander, Jennifer;Sui, Xuemei;Hebert, James R.
冠心病（CHD）在美国仍然是导致死亡的主要原因。心脏病风险评分（FRS）是为了帮助临床医生确定患者的冠心病风险而开发的。我们假设，FRS将显着预测冠心病事件的男性在有氧运动中心纵向研究（ACLS）population.MethodsOur研究包括34,557名男性谁出席了库珀诊所在达拉斯，得克萨斯州，基线临床检查，从1972年到2002年。CHD事件包括自我报告的心肌梗死或血运重建或CHD导致的死亡。在12年的随访中，发生了587例CHD事件。从ACLS分析产生的多变量调整的风险比进行了比较与FRS的应用程序的Frachial心脏研究（FHS）。调整后的考克斯比例风险模型显示，总胆固醇280 mg/dL或更高的男性是2.21（95%可信区间（CI），1.59-3.09）倍于总胆固醇为160 - 199 mg/dL的男性发生CHD事件的可能性;男性糖尿病患者发生CHD事件的可能性是非糖尿病患者的1.63倍（95%CI，1.35-1.98）。据我们所知，这是第一份通过广泛的实验室和临床测量来验证FRS的大型单中心队列研究报告。
IntroductionCoronary heart disease (CHD) remains a leading cause of death in the United States. The Framingham Risk Score (FRS) was developed to help clinicians in determining their patients' CHD risk. We hypothesize that the FRS will be significantly predictive of CHD events among men in the Aerobics Center Longitudinal Study (ACLS) population.MethodsOur study consisted of 34,557 men who attended the Cooper Clinic in Dallas, Texas, for a baseline clinical examination from 1972 through 2002. CHD events included self-reported myocardial infarction or revascularization or death due to CHD. During the 12-year follow-up 587 CHD events occurred. Multivariable-adjusted hazard ratios generated from ACLS analysis were compared with the application of FRS to the Framingham Heart Study (FHS).ResultsThe ACLS cohort produced similar hazard ratios to the FHS. The adjusted Cox proportional hazard model revealed that men with total cholesterol of 280 mg/dL or greater were 2.21 (95% confidence interval (CI), 1.59-3.09) times more likely to have a CHD event than men with total cholesterol from 160 through 199mg/dL; men with diabetes were 1.63 (95% CI, 1.35-1.98) times more likely to experience a CHD event than men without diabetes.ConclusionThe FRS significantly predicts CHD events in the ACLS cohort. To the best of our knowledge, this is the first report of a large, single-center cohort study to validate the FRS by using extensive laboratory and clinical measurements.