Genetic variation among hepatitis B and related viruses.
Genetic variation among hepatitis B and related viruses.
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乙型肝炎和相关病毒之间的遗传变异。
DOI：
10.1111/j.1749-6632.1980.tb27978.x
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发表时间：
1980
影响因子：
5.2
通讯作者：
Robinson,WS
中科院分区：
文献类型：
--
作者：
Robinson,WS
人类的B型肝炎病毒（HBV）具有几个区别于其他组的病毒的特征。这些包括其超微结构，病毒DNA大小和结构，修复病毒DNA单链区域的病毒体DNA聚合酶，肝嗜性，持续感染的特征，以及与肝炎和肝细胞癌的关系。最近，在其他动物物种中发现了另外三种病毒，它们似乎具有这些特征，尽管这些病毒并不完全相同。HBV、土拨鼠肝炎病毒（WHV）、地松鼠肝炎病毒（GSHV）和鸭肝炎病毒（DHV）似乎是一个新的病毒组的成员，可能被命名为Hepadna病毒组。B型肝炎病毒的遗传变异包括表面抗原（HBsAg）的抗原性变异，它构成了已知的HBsAg亚型。从不同患者分离的HBV之间的DNA碱基序列也经常发生变异。
Hepatitis B virus (HBV) of man has several characteristics that distinguish it from viruses of other groups. These include its ultrastructure, viral DNA size and structure, a virion DNA polymerase which repairs a single-stranded region in the viral DNA, liver tropism, character of persistent infection, and association with hepatitis and hepatocellular carcinoma. Recently three other viruses have been found in other animal species that appear to share these characteristics although the viruses are not identical. HBV, Woodchuck hepatitis virus (WHV), ground squirrel hepatitis virus (GSHV), and duck hepatitis virus (DHV) appear to be members of a new virus group that might be designated the Hepadna virus group. Genetic variation among hepatitis B viruses includes the antigenic variation in the surface antigen (HBsAg) which constitutes the known HBsAg subtypes. There is also frequent variation in DNA base sequence among HBVs isolated from different patients.