Gastroesophageal reflux disease:: Prevalence, clinical, endoscopic and histopathological findings in 1,128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms
Gastroesophageal reflux disease:: Prevalence, clinical, endoscopic and histopathological findings in 1,128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms
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DOI：
10.1159/000007730
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发表时间：
2000-01-01
期刊：
影响因子：
3.2
通讯作者：
Färkkilä, M
中科院分区：
文献类型：
--
作者：
Voutilainen, M;Sipponen, P;Färkkilä, M
背景和目的：据报道，胃食管反流病（GERD）的患病率有所增加，而幽门螺杆菌感染和消化性溃疡病的患病率却在下降。本研究的目的是检查转诊内镜检查患者中 GERD 的患病率以及与 GERD 相关的临床、内镜和组织学变量。患者和方法：研究人群来自 1,562 名连续接受内窥镜检查的患者。排除标准是既往根除幽门螺杆菌、胃手术、贫血和体重减轻。因此，1,128 名患者参加了本研究。结果：在 1,128 名患者中，199 名 (18%) 因胃灼热和/或反流而转诊接受内窥镜检查。 GERD 定义为慢性（>6 个月）胃灼热和/或反流，伴或不伴糜烂性食管炎、巴雷特食管、食管溃疡或狭窄，在 248 名 (22%) 患者中检测到。在 248 名 GERD 患者中，81 名 (33%) 内镜检查阴性 GERD，但年龄较大的患者中
Background and Aims: Gastroesophageal reflux disease (GERD) reportedly has increased in prevalence while Helicobacter pylori infection and peptic ulcer disease have been on the decrease. The aim of the present study was to examine the prevalence of GERD as well as the clinical, endoscopic and histologic variables that associate with GERD in patients referred for endoscopy. Patients and Methods: The study population was drawn from 1,562 consecutive patients referred for endoscopy. The exclusion criteria were previous H. pylori eradication, gastric surgery, anemia and weight loss. Thus 1,128 patients were enrolled in the present study. Results: Of the 1,128 patients, 199 (18%) were referred for endoscopy due to heartburn and/or regurgitation. GERD, defined as chronic (>6 months) heartburn and/or regurgitation with or without erosive esophagitis, Barrett's esophagus, esophageal ulcer or stricture, was detected in 248 (22%) patients. Of the 248 GERD patients, 81 (33%) had endoscopy-negative GERD, but of those aged