Protein-protein interactions as targets for small molecule drug discovery
Protein-protein interactions as targets for small molecule drug discovery
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DOI：
10.1002/bip.20608
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发表时间：
2006-01-01
期刊：
影响因子：
2.9
通讯作者：
Fry, David C.
中科院分区：
文献类型：
--
作者：
Fry, David C.
蛋白质-蛋白质相互作用代表了药物发现的一类高度密集的靶标。然而，此类系统存在许多独特的挑战。这篇综述对个体蛋白质-蛋白质相互作用系统进行了分析，该系统最近在发现类药物抑制剂方面取得了成功。重点关注蛋白质结合位点的结构特征和小分子配体的属性，试图得出共同的原则，这些原则可能在该目标类别的未来药物发现工作中普遍有用。 (c) 2006 年 Wiley 期刊公司
Protein-protein interactions represent a highly populated class of targets for drug discovery. However, such systems present a number of unique challenges. This review presents an analysis of individual protein-protein interaction systems which have recently yielded success in discovering drug-like inhibitors. The structural characteristics of the protein binding sites and the attributes of the small molecule ligands are focused upon, in an attempt to derive commonly shared principles that may be of general usefulness in future drug discovery efforts within this target class. (c) 2006 Wiley Periodicals, Inc.