Stimulation of rat placental cell DNA synthesis by transferrin.
Stimulation of rat placental cell DNA synthesis by transferrin.
复制标题
转铁蛋白刺激大鼠胎盘细胞 DNA 合成。
DOI：
10.1095/biolreprod38.5.1123
复制
发表时间：
1988
影响因子：
3.6
通讯作者：
Soares,MJ
中科院分区：
文献类型：
--
作者：
De,M;Hunt,JS;Soares,MJ
The purpose of the present investigation was to evaluate the in vitro requirements for rat placental cell DNA synthesis. A cell line established from the labyrinth region of midgestation rat chorioallantoic placentas was used to examine the actions of various agents. Transferrin was found to stimulate rat placental cell DNA synthesis and cell proliferation. The effects of transferrin on rat placental cell growth paralleled those observed with fetal bovine serum. Rat placental cells were responsive to both rat and human transferrin. Iron-saturated (holo-) transferrin was a more potent stimulator of rat placental cell DNA synthesis than was iron-free (apo-) transferrin. Addition of insulin, epidermal growth factor, or insulin-like growth factor-II to serum-free medium supplemented with rat transferrin did not significantly enhance rat placental cell DNA synthesis beyond that observed with only transferrin. The results demonstrate that a population of cells exists within the rat chorioallantoic placenta that are highly responsive to transferrin.
