SHARING OF THE INTERLEUKIN-2 (IL-2) RECEPTOR GAMMA-CHAIN BETWEEN RECEPTORS FOR IL-2 AND IL-4
SHARING OF THE INTERLEUKIN-2 (IL-2) RECEPTOR GAMMA-CHAIN BETWEEN RECEPTORS FOR IL-2 AND IL-4
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DOI：
10.1126/science.8266076
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发表时间：
1993-12-17
期刊：
影响因子：
56.9
通讯作者：
SUGAMURA, K
中科院分区：
文献类型：
--
作者：
KONDO, M;TAKESHITA, T;SUGAMURA, K
白细胞介素-2（IL-2）受体的γ链是IL-2结合和细胞内信号转导不可缺少的亚基。γ链的单克隆抗体TUGm 2抑制IL-2与功能性IL-2受体的结合，也抑制IL-4诱导的细胞生长和IL-4与CTLL-2小鼠T细胞系的高亲和力结合。另一种与IL-2交联的γ链反应的单克隆抗体TUGm 3在与IL-4交联时也免疫沉淀γ链。这些结果表明IL-2受体γ链在功能上参与IL-4受体复合物。
The gamma chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the gamma chain cross-linked with IL-2, also immunoprecipitated the gamma chain when cross-linked with IL-4. These results suggest that the IL-2 receptor gamma chain is functionally involved in the IL-4 receptor complex.