Long Noncoding RNAs: A New Regulatory Code in Metabolic Control.
Long Noncoding RNAs: A New Regulatory Code in Metabolic Control.
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DOI：
10.1016/j.tibs.2015.08.002
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发表时间：
2015-10
影响因子：
13.8
通讯作者：
Lin JD
中科院分区：
文献类型：
--
作者：
Zhao XY;Lin JD
长链非编码RNA（lncRNA）正在成为基因组中编码的调节信息的组成部分。LncRNA具有与核酸和蛋白质相互作用的独特能力，并对许多生物过程产生离散效应。最近的研究已经描绘了控制代谢组织发育和功能的多个lncRNA通路。将营养和激素信号与组织代谢联系起来的调节代码的扩展为代谢疾病的遗传和致病机制提供了新的见解。这篇综述讨论了lncRNA生物学，重点是它在关键代谢组织的发育，信号传导和功能中的作用。
Long noncoding RNAs (lncRNAs) are emerging as an integral part of the regulatory information encoded in the genome. LncRNAs possess the unique capability to interact with nucleic acids and proteins and exert discrete effects on numerous biological processes. Recent studies have delineated multiple lncRNA pathways that control metabolic tissue development and function. The expansion of the regulatory code that links nutrient and hormonal signals to tissue metabolism gives new insights into the genetic and pathogenic mechanisms underlying metabolic disease. This review discusses lncRNA biology with a focus on its role in the development, signaling, and function of key metabolic tissues.