Fruit and vegetable consumption and cognitive decline in aging women
Fruit and vegetable consumption and cognitive decline in aging women
复制标题
DOI：
10.1002/ana.20476
复制
发表时间：
2005-05-01
影响因子：
11.2
通讯作者：
Grodstein, F
中科院分区：
文献类型：
--
作者：
Kang, JH;Ascherio, A;Grodstein, F
我们前瞻性地研究了水果和蔬菜摄入量与老年妇女认知功能和衰退的关系。参与者从1976年开始每两年进行一次问卷调查，1984年和1986年进行食物频率问卷调查，此后每4年进行一次。从1995年到2001年，我们通过电话进行了六次认知测试，测量了一般认知、非文字记忆、类别流畅性和工作记忆。两年后，我们对13，388名女性进行了重复评估（> 90%的随访）。我们从1984年到第一次认知评估的平均饮食摄入量，并使用线性回归获得多变量调整后的平均差异的性能和性能下降的摄入水平。水果与认知或认知能力下降无关。然而，蔬菜总摄入量与下降幅度较小显著相关。具体而言，在综合所有测试的总体得分上，与最低的五分之一相比，十字花科蔬菜最高五分之一的女性下降较慢（0.04个单位; 95%置信区间，0.003，0.07; p趋势= 0.1）。消费最多绿色叶菜的女性也比消费最少的女性经历了更慢的下降（0.05单位; 95%置信区间，0.02，0.09; p趋势< 0.001）。这些平均差异相当于在年龄相差约1至2岁的女性中观察到的差异。
We prospectively examined fruit and vegetable intake in relation to cognitive function and decline among aging women. Participants were followed from in 1976 with biennial questionnaires, and food frequency questionnaires were administered in 1984, 1986, and every 4 years thereafter. From 1995 to 2001, we administered, by telephone, six cognitive tests measuring general cognition, verbal memory, category fluency, and working memory. We repeated assessments two years later for 13,388 women (> 90% follow-up). We averaged dietary intakes from 1984 through the first cognitive assessment, and used linear regression to obtain multivariable-adjusted mean differences in performance and decline in performance across intake levels. Fruits were not associated with cognition or cognitive decline. However, total vegetable intake was significantly associated with less decline. Specifically, on a global score combining all tests, women in the highest quintile of cruciferous vegetables declined slower (by 0.04 unit; 95% confidence interval, 0.003, 0.07; p trend = 0.1) compared with the lowest quintile. Women consuming the most green leafy vegetables also experienced slower decline than women consuming the least amount (by 0.05 unit; 95% confidence interval, 0.02, 0.09; p trend < 0.001). These mean differences were equivalent to those observed for women about I to 2 years apart in age.