ISOLATION AND BIOLOGICAL-ACTIVITY OF THIELOCINS - NOVEL PHOSPHOLIPASE-A(2) INHIBITORS PRODUCED BY THIELAVIA-TERRICOLA-RF-143
ISOLATION AND BIOLOGICAL-ACTIVITY OF THIELOCINS - NOVEL PHOSPHOLIPASE-A(2) INHIBITORS PRODUCED BY THIELAVIA-TERRICOLA-RF-143
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DOI：
10.7164/antibiotics.48.106
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发表时间：
1995-02-01
影响因子：
3.3
通讯作者：
YOSHIDA, T
中科院分区：
文献类型：
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作者：
MATSUMOTO, K;TANAKA, K;YOSHIDA, T
硫菌素 A2 α、A2 β、A3、B1、B2 和 B3 作为新型磷脂酶 A(2) 抑制剂家族，与硫菌素和硫菌素 A1 α 和 A1 β 一起从土生梭孢壳 RF-143 的发酵液中分离出来。 thielocin A1 beta 对大鼠 II 组磷脂酶 A(2) 表现出最有效的抑制活性 (IC50=0.0033 mu M)。针对人类 II 组磷脂酶 A(2)，硫菌素 B3 (IC50=0.076 muM) 是最有效的。
Thielocins A2 alpha, A2 beta, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A(2) inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1 alpha and A1 beta. The most potent inhibitory activity (IC50=0.0033 mu M) against rat group II phospholipase A(2) was shown by thielocin A1 beta. Against human group II phospholipase A(2), thielocin B3 (IC50=0.076 mu M) was the most potent.