p38? activity is required for maintenance of slow skeletal muscle size
p38? activity is required for maintenance of slow skeletal muscle size
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DOI：
10.1002/mus.22289
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发表时间：
2012-02-01
期刊：
影响因子：
3.4
通讯作者：
Wang, Yibin
中科院分区：
文献类型：
--
作者：
Foster, William H.;Tidball, James G.;Wang, Yibin
简介：p38？肌酸激酶在骨骼肌中高度丰富，与肌管的形成有关。然而，p38？在肌肉中的作用尚不清楚。方法：检测慢速和快速成年小鼠骨骼肌组织中p38c活性，以及p38c缺乏对肌肉发育和基因表达的影响。结果：p38c在慢肌中优先激活，在快肌中不激活。此外，在小鼠中，p38c的丢失导致了与慢肌中较小的肌纤维直径相关的肌肉质量的减少，但对快肌的质量或肌纤维直径都没有影响。最后，p38c基因缺失的肌肉在慢肌纤维中表现出与肌肉生长相关的基因的选择性变化。结论：本研究为p38c在慢速骨骼肌中选择性激活提供了证据，并参与了一部分骨骼肌的正常生长发育。肌肉神经45：266-273,2012
Introduction: p38? kinase is highly enriched in skeletal muscle and is implicated in myotube formation. However, the activation status of p38? in muscle is unclear. Methods: p38c activity in slow and fast adult mouse skeletal muscle tissue was examined, as was the impact of p38c deficiency on muscle development and gene expression. Results: p38c is preferentially activated in slow muscle, but it is inactive in fast muscle types. Furthermore, the loss of p38c in mice led to decreased muscle mass associated with a smaller myofiber diameter in slow muscle, but there was no impact on fast muscle in either mass or myofiber diameter. Finally, p38c-deficient muscle showed selective changes in genes related to muscle growth in slow muscle fibers. Conclusion: This study provides evidence that p38c is selectively activated in slow skeletal muscle and is involved in the normal growth and development of a subset of skeletal muscle. Muscle Nerve 45: 266-273, 2012