Clock genes in hypertension: novel insights from rodent models.
Clock genes in hypertension: novel insights from rodent models.
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DOI：
10.1097/mbp.0000000000000060
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发表时间：
2014-10
影响因子：
1.3
通讯作者：
Gumz ML
中科院分区：
文献类型：
--
作者：
Richards J;Diaz AN;Gumz ML
The circadian clock plays an integral role in the regulation of physiological processes, including the regulation of blood pressure. However, deregulation of the clock can lead to pathophysiological states including hypertension. Recent work has implicated the circadian clock genes in the regulation of processes in the heart, kidney, vasculature, and the metabolic organs, which are all critical in the regulation of the blood pressure. The goal of this review is to provide an introduction and general overview into the role of circadian clock genes in the regulation of blood pressure with a focus on their deregulation in the etiology of hypertension. This review will focus on the core circadian clock genes CLOCK, BMAL1, Per, and Cry.
