ACTION POTENTIAL IN MYELINATED NERVE FIBRE OF XENOPUS LAEVIS AS COMPUTED ON BASIS OF VOLTAGE CLAMP DATA
ACTION POTENTIAL IN MYELINATED NERVE FIBRE OF XENOPUS LAEVIS AS COMPUTED ON BASIS OF VOLTAGE CLAMP DATA
复制标题
DOI：
10.1113/jphysiol.1964.sp007378
复制
发表时间：
1964-01-01
影响因子：
5.5
通讯作者：
HUXLEY, AF
中科院分区：
文献类型：
--
作者：
FRANKENHAEUSER, B;HUXLEY, AF
数字计算机上的计算是根据早期在非洲爪蟾有髓鞘神经纤维实验中获得的电压钳数据进行的。获得了膜动作电位被释放的情况的解决方案。图表显示了计算出的动作电位；渗透率变量 m、h、n 和 p；磁导率 PNa、Pk 和 Pp；膜电导G；离子电流 INa、IK、Ip 和 IL。对电压钳数据的简单改变进行了进一步的计算。将溶液与记录的膜动作电位进行比较。结论是电压钳数据预测的动作电位与记录的动作电位令人满意地一致。因此，除了电压钳分析中描述的电流之外，不需要具有明显幅度的电流来解释有髓神经纤维中的脉冲活动。
Computations on a digital computer were made from the voltage clamp data obtained earlier in experiments on the myelinated nerve fiber of Xenopus laevis. Solutions were obtained for the situation where a membrane action potential was discharged. Graphs are presented showing the calculated action potential; permeability variables m, h, n and p; permeabilities PNa, Pk and Pp; membrane conductance G; ionic currents INa, IK, Ip and IL. Computations were further made for simple changes of the voltage-clamp data. The solutions are compared with recorded membrane action potentials. It is concluded that the voltage clamp data predict an action potential which agrees satisfactorily with recorded action potentials. Currents of an appreciable amplitude, others than those described in the voltage clamp analysis, are there-fore not required to explain the impulse activity in the myelinated nerve fiber.