Evaluation of dementia in the cardiovascular health cognition study
Evaluation of dementia in the cardiovascular health cognition study
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DOI：
10.1159/000067110
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发表时间：
2003-01-01
影响因子：
5.7
通讯作者：
Beauchamp, N
中科院分区：
文献类型：
--
作者：
Lopez, OL;Kuller, LH;Beauchamp, N
目的：描述一种评估痴呆、不同类型痴呆的频率和心血管健康研究（CHS）患病率的方法。方法：CHS是一项针对65岁以上社区居民心血管疾病的纵向研究。在最初研究的5888名参与者中，有3608人在1991年接受了大脑磁共振成像（MRI）检查，并组成了痴呆研究的队列。CHS包括每年对认知功能的测量，从1998年到2000年，参与者通过详细的神经学和神经心理学检查来评估痴呆症。痴呆和轻度认知障碍（MCI）的可能病例由神经学家和精神病学家组成的审查委员会裁定。结果：共480例（13.3%）痴呆，227例（6.3%）痴呆，577例（16.0%）MCI， 2318例（64.4%）正常。评审委员会将69%的痴呆事件归为阿尔茨海默病（AD）， 11%归为血管性痴呆（VaD）， 16%归为两者，4%归为其他类型。mri前和mri后对痴呆类型的诊断有很大的一致性。在1998-1999年研究结束时幸存的CHS队列中，老年痴呆症的发病率在白人男性中为13.5%，白人女性为14.5%，黑人男性为22.2%，黑人女性为23.4%。结论：CHS开发了一种大型队列痴呆纵向研究方法，是包括认知测试、MRI和遗传标记在内的最大规模的痴呆研究。版权所有(C) 2003 S. Karger AG，巴塞尔。
Objective: To describe a methodology to evaluate dementia and frequency of different types of dementia and prevalence of the Cardiovascular Health Study (CHS). Methods: The CHS is a longitudinal study of cardiovascular disease among community-dwelling individuals over the age of 65. Of the 5,888 participants in the original study, 3,608 had a magnetic resonance imaging (MRI) of the brain in 1991, and formed the cohort for the dementia study. The CHS included yearly measures of cognitive function and, from 1998 to 2000, participants were evaluated for dementia by detailed neurological, and neuropsychological examinations. The possible cases of dementia and mild cognitive impairment (MCI) were adjudicated by a review committee of neurologists and psychiatrists. Results:There were 480 cases of (13.3%) incident dementia in the total sample, 227 (6.3%) prevalent dementia, 577 (16.0%) MCI, and 2,318 (64.4%) normal. The adjudication committee classified 69% of the incident dementia as Alzheimer's disease (AD), 11% as vascular dementia (VaD), 16% as both, and 4% as other types. There was a substantial agreement between pre- and postMRI diagnosis of types of dementia. The frequency of dementia within the CHS cohort which survived to the end of the study in 1998-1999, was 13.5% for white men, 14.5% for white women, 22.2% for black men and 23.4% for black women. Conclusion: The CHS has developed a methodology for longitudinal studies of dementia in large cohorts and represents the largest study of dementia including cognitive testing, MRI and genetic markers. Copyright (C) 2003 S. Karger AG, Basel.