Parental hypertension and cardiovascular response to stress in healthy young adults.
Parental hypertension and cardiovascular response to stress in healthy young adults.
复制标题
健康年轻人父母高血压和心血管对压力的反应。
DOI：
10.1111/j.1469-8986.1982.tb02512.x
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发表时间：
1982
期刊：
影响因子：
3.7
通讯作者：
Obrist,PA
中科院分区：
文献类型：
--
作者：
Hastrup,JL;Light,KC;Obrist,PA
原发性高血压后续发展风险升高的一个指标是父母一方或双方存在这种疾病。心血管对压力的反应性也被认为是高血压的可能前兆。本研究检测了103名健康大学生男性在两种静息状态和压力冷加压和反应时间任务中，父母高血压与心率（HR）、收缩压（SBP）和舒张压（DBP）水平之间的关系。高血压的父母（N = 25）的儿子比血压正常的父母（N = 78）的儿子在休息和压力表现出更高的HR和SBP，但这些差异在应激反应时间（RT）的任务。未观察到DBP的可靠差异。45名受试者（包括14名父母患有高血压的受试者）的子样本也在第二次应激（冷加压试验）期间进行了监测;在这种应激中，只观察到与父母高血压相关的HR或BP差异趋势，尽管RT任务期间的HR和SBP差异仍然显着（p <0.05），即使在这个较小的群体中。由于已知高血压父母的后代中高血压的发病率更高，这些发现表明，对某些类型的压力（例如，积极应对任务）可能有助于预测未来高血压的风险。
One indicator of elevated risk for subsequent development of essential hypertension is the presence of the disorder in either or both parents. Exaggerated cardiovascular responsivity to stress has also been suggested as a possible precursor to hypertension. This study examined the relationship between parental hypertension and the heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP) levels of 103 healthy college‐age men, during two resting conditions and stressful cold pressor and reaction time tasks. Sons of hypertensive parents (N = 25) showed higher HR and SBP than sons of normotensive parents (N = 78) during both rest and stress, but these differences were greatest during the stressful reaction time (RT) task. No reliable differences in DBP were seen. A subsample of 45 subjects, including 14 with hypertensive parents, were also monitored during a second stress, the cold pressor test; only trends toward HR or BP differences related to parental hypertension were seen for this stress, although HR and SBP differences during the RT task were still significant (p<.05) even in this smaller group. Since the incidence of high blood pressure is known to be greater among the offspring of hypertensive parents, these findings suggest that cardiovascular responses to certain types of stress (e.g., active coping tasks) may help predict future risk of hypertension.