Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts.
Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts.
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DOI：
10.1021/jacs.5b03937
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发表时间：
2015-07-01
影响因子：
15
通讯作者：
Gaunt MJ
中科院分区：
文献类型：
--
作者：
Cahard E;Male HP;Tissot M;Gaunt MJ
描述了烯烃的催化对映选择性和区域发散芳基化。手性双恶唑啉铜 (II) 络合物可催化二芳基碘鎓盐与烯丙酰胺的加成反应，具有优异的 ee 效果。此外，芳基化可以通过二芳基碘鎓盐的电子性质来控制，从而能够制备非外消旋二芳基恶嗪或β,β'-二芳基烯酰胺。
A catalytic enantioselective and regiodivergent arylation of alkenes is described. Chiral copper(II)bisoxazoline complexes catalyze the addition of diaryliodonium salts to allylic amides in excellent ee. Moreover, the arylation can be controlled by the electronic nature of the diaryliodonium salt enabling the preparation of nonracemic diaryloxazines or β,β′-diaryl enamides.