Nonencapsulated Variant of Cryptococcus neoformans I. Virulence Studies and Characterization of Soluble Polysaccharide
Nonencapsulated Variant of Cryptococcus neoformans I. Virulence Studies and Characterization of Soluble Polysaccharide
复制标题
新型隐球菌的非包膜变种 I. 可溶性多糖的毒力研究和表征
作者：
T. Kozel;J. Cazin
描述了新型隐球菌的弱毒力非包膜变体。比较了变异株与典型毒力株产生的可溶性多糖的化学结构和抗原性。两种菌株产生的可溶性多糖均由相同的单糖组成；然而，与变异菌株相比，强毒菌株产生的多糖具有更高的糖醛酸含量和更大的分子尺寸。两种菌株的可溶性多糖在免疫学上并不密切相关。从强毒株中获得的可溶性多糖不影响变异株在小鼠体内的持久性。
A weakly virulent nonencapsulated variant of Cryptococcus neoformans is described. The chemical structure and antigenicity of the soluble polysaccharides produced by the variant strain and a typical virulent strain were compared. The soluble polysaccharides produced by both strains were composed of the same constituent monosaccharides; however, the virulent strain produced a polysaccharide having a greater uronic acid content and a larger molecular size than that of the variant strain. Soluble polysaccharides from the two strains are not closely related immunologically. Soluble polysaccharide obtained from the virulent strain did not affect persistence of the variant strain in mice.