Dietary folate intakes and effects of folic acid supplementation on folate concentrations among Japanese pregnant women
Dietary folate intakes and effects of folic acid supplementation on folate concentrations among Japanese pregnant women
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DOI：
10.1111/j.1447-0756.2010.01358.x
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发表时间：
2011-04-01
影响因子：
1.6
通讯作者：
Shimosuka, Yoichi
中科院分区：
文献类型：
--
作者：
Kondo, Atsuo;Asada, Yoshimasa;Shimosuka, Yoichi
目的：量化膳食叶酸的摄入量，并评估叶酸和平衡膳食对血清叶酸浓度的影响。材料与方法：收集2003年至2008年6年期间641名孕妇的食物记录，以量化膳食叶酸的摄入量。2008年对80例孕妇进行了叶酸片和平衡膳食的对比研究。结果：孕妇膳食叶酸摄入量平均为331 μ g/d，其中200例孕妇在孕早期的膳食叶酸摄入量最少，为294 μ g/d。据观察，200名妇女中有42%的人每天摄入至少440微克的膳食叶酸或每天服用400微克的叶酸补充剂，但其中58%的人既不摄入440微克的膳食叶酸，也不服用叶酸补充剂。摄入400亩叶酸补充剂5周导致血清叶酸浓度显着增加，但平衡饮食的消费没有影响增加叶酸concentration.Conclusions：膳食叶酸的平均摄入量没有达到推荐的膳食津贴440亩。只有服用叶酸补充剂的孕妇血清叶酸浓度显著升高。建议消费均衡的饮食似乎并不能有效地降低神经管缺陷的发生率。
Aim:To quantify the consumed amount of dietary folate and to evaluate effects of folic acid and balanced diets on serum folate concentrations.Material & Methods:Food records collected from 641 pregnant women were assessed to quantify the consumed amount of dietary folate for a 6-year period from 2003 to 2008. Changes in serum folate concentrations were evaluated among 80 pregnant women who either took folic acid tablets or consumed balanced diets in 2008.Results:Though the dietary folate intake averaged 331 mu g daily, 200 women in the 1st trimester consumed the least amount of dietary folate, 294 mu g daily. It was observed that 42% of the 200 women either consumed at least 440 mu g of dietary folate daily or took 400 mu g folic acid supplements daily, but that 58% of them neither consumed dietary folate of 440 mu g nor took folic acid supplements. Intakes of 400 mu g folic acid supplements for 5 weeks resulted in a significant increase in serum folate concentrations but the consumption of balanced diets had no effect on increasing folate concentrations.Conclusions:The average intake of dietary folate did not fulfill the Recommended Dietary Allowance of 440 mu g. Serum folate concentration significantly increased only among pregnant women who took folic acid supplements. Recommendations to consume balanced diets do not seem effective to decrease the incidence of neural tube defects.