TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance
TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance
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DOI：
10.1016/s0968-0004(03)00037-9
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发表时间：
2003-04-01
影响因子：
13.8
通讯作者：
van der Oost, J
中科院分区：
文献类型：
--
作者：
Ettema, TJG;Huynen, MA;van der Oost, J
We describe a previously undetected domain - TRASH containing a well-conserved cysteine motif that we anticipate to be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated.
