FATTY-ACID UTILIZATION IN PERINATAL DENOVO SYNTHESIS OF TISSUES
FATTY-ACID UTILIZATION IN PERINATAL DENOVO SYNTHESIS OF TISSUES
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DOI：
10.1016/0378-3782(81)90016-5
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
CHANCE, GW
中科院分区：
文献类型：
--
作者：
CLANDININ, MT;CHAPPELL, JE;CHANCE, GW
胎儿组织中的脂肪酸含量被用来估计胎儿宫内生长过程中必需脂肪酸的增加。这些必需脂肪酸的增加速度被用来预测每天400毫克/公斤的人体重量(ω-6脂肪酸)和50毫克/公斤的身体重量(ω-3脂肪酸)将用于组织的宫内合成。针对.apprx的高危低出生体重儿。1300g出生体重，可以计算出宫外组织合成将利用.apprx。根据在组成上类似于胎儿内生长的预计生长速度，对于ω-6脂肪酸，280毫克/公斤的身体重量和对于ω-3脂肪酸的大约35毫克/公斤的身体重量，并且相当于每天17克的增长。从棕色和白色脂肪组织的脂肪酸分析估计，这些必需脂肪酸的全身净增加率中，约有70%和78%代表脂肪器官中的欧米伽-6和欧米伽-3脂肪酸积累。利用哺乳期第16天母乳中的脂肪酸分析来估计低出生体重儿的主要必需脂肪酸和其他脂肪酸的日摄入量。对于120千卡/公斤的摄入量，得出的结论是，母亲自己的乳汁中的必需脂肪酸含量提供了6650。345毫克总脂肪酸，850+-。160毫克欧米伽-6脂肪酸和140+-。17毫克欧米伽-3脂肪酸。
The fatty acid content of fetal tissues was utilized to estimate essential fatty acid accretion during intrauterine growth. These rates of essential fatty acid accretion were used to predict that 400 mg/kg of body wt for .omega.-6 fatty acids and 50 mg/kg of body wt for .omega.-3 fatty acids per day would be used for intrauterine de novo synthesis of tissues. For the high risk low birth weight infant of .apprx. 1300 g birthweight it can be calculated that extrauterine de novo tissue synthesis would utilize .apprx. 280 mg/kg of body wt for .omega.-6 fatty acids and about 35 mg/kg of body wt for .omega.-3 fatty acids based on projected growth rates that are similar in composition to intrauterine growth and amount to 17 g of gain/day. From fatty acid analysis of brown and white adipose tissue it was estimated that some 70 and 78% of these net whole body accretion rates for essential fatty acids represent .omega.-6 and .omega.-3 fatty acid accretion in the adipose organs. Fatty acid analysis of human milk at day 16 of lactation was utilized to estimate the low birth weight infants'' daily intake of major essential and other fatty acids. For intake levels of 120 kcal/kg it was concluded that the essential fatty acid content of mothers'' own milk provides 6650 .+-. 345 mg of total fatty acids, 850 .+-. 160 mg of .omega.-6 fatty acids and 140 .+-. 17 mg of .omega.-3 fatty acids.