β‐Endorphin Immunoreactivity and Acute Behavioral Distress in Children with Leukemia
β‐Endorphin Immunoreactivity and Acute Behavioral Distress in Children with Leukemia
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白血病儿童的β-内啡肽免疫反应性和急性行为困扰
DOI：
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发表时间：
1982
影响因子：
1.9
通讯作者：
S. Siegel
中科院分区：
文献类型：
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作者：
E. Katz;B. Sharp;J. Kellerman;A. Marston;J. Hershman;S. Siegel
内源性阿片类药物与疼痛和压力经历有关。为了直接评估内啡肽活性与急性行为困扰之间的关系，采用放射免疫法检测75例常规腰椎穿刺的急性白血病患儿脑脊液中的β-内啡肽免疫反应性（β-EPI）。这些数据与手术过程中收集的四项行为困扰指标相关。对于 4 岁及以上儿童，β-EPI 与年龄成反比（r = -.31，p ≤ .05）。所有行为测量也与年龄呈负相关（r = -.26 至 -.67，p ≤ .05 至 .001）。女性的平均 β-EPI 显着低于男性 (p ≤ .01)，并且表现出更大的行为困扰。 β-EPI 和行为测量与特定抗白血病药物的使用相互作用。 L-天冬酰胺酶与较低的 β-EPI (p ≤ .05) 相关，而泼尼松在四项指标中的三项中与较低的行为困扰相关 (p ≤ .05 至 .01)。在控制年龄、性别和化疗后，β-EPI 和护士焦虑评分呈正相关（偏相关系数 = .31，p ≤ .05）。 β-EPI 和其他行为测量之间的相关性显示出积极的趋势。这项研究的结果被解释为支持脑脊液中 β-EPI 对急性应激的反应性质，并可能有助于解释记录在案的应激行为中的性别差异。讨论了潜在的临床意义和进一步研究的方向。
Endogenous opiates have been implicated in pain and stress experiences. In order to directly assess the relationship between endorphin activity and acute behavioral distress, β-endorphin immunoreactivity (β-EPI) was measured by radioimmunoassay in cerebrospinal fluid of 75 children with acute leukemia undergoing routine lumbar puncture. These data were related to four measures of behavioral distress collected during the procedure. For children 4 years of age and above, β-EPI correlated inversely with age (r = -.31, p ≤ .05). All behavioral measures also inversely correlated with age (r = -.26 to -.67, p ≤ .05 to .001). Females had a significantly lower mean β-EPI than males (p ≤ .01), and exhibited greater behavioral distress. β-EPI and behavioral measures interacted with the use of specific antileukemia agents. L-Asparaginase was associated with lower β-EPI (p ≤ .05), while prednisone was associated with lower behavioral distress on three of the four measures (p ≤ .05 to .01). After controlling for age, sex, and chemotherapy, β-EPI and nurse ratings of anxiety were positively correlated (partial correlation coefficient = .31, p ≤ .05). Correlations between β-EPI and other behavioral measures demonstrated positive trends. Results of this study are interpreted as support for the reactive nature of β-EPI in cerebrospinal fluid to acute distress, and may help explain documented sex differences in distress behavior. Potential clinical implications and directions for further research are discussed.