Sexual activity modulates neuroinflammatory responses in male rats.
Sexual activity modulates neuroinflammatory responses in male rats.
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性活动调节雄性大鼠的神经炎症反应。
DOI：
10.1016/j.physbeh.2018.09.009
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发表时间：
2018
影响因子：
2.9
通讯作者：
Glasper,EricaR
中科院分区：
文献类型：
--
作者：
Pyter,LeahM;Bever,SavannahR;Khantsis,Sabina;Glasper,EricaR
免疫活动影响生殖，然而，交配经历可能在多大程度上相反地改变免疫途径却知之甚少。一些对人类的研究表明，交配会触发循环免疫和下丘脑-垂体-肾上腺轴反应。在雄性大鼠中，交配经历增强了神经可塑性，改善了认知功能和类似情感的行为，而不依赖于身体活动的成分。然而，交配经历可能在多大程度上影响大脑中的免疫反应仍未得到探索。在这里，我们假设最近在雄性大鼠身上的交配经历增加了神经炎性信号(通过内毒素刺激，I.P.)以及与性幼稚对照相关的疾病行为(即食物摄入量、体重减轻)。处女雄性大鼠连续6天暴露于性不接受(对照)或性接受的雌性大鼠30 分钟。在最后一次交配后，立即给大鼠注射生理盐水或脂多糖，并在4小时后安乐死。交配增加了脑部对脂多糖的α反应，这与脂多糖诱导的体重减轻呈正相关。交配也增加了盐水处理大鼠的外周皮质酮，但这种皮质酮反应在最熟练的交配者中减弱(例如，最短的潜伏期)。因此，最近的交配经历可能是与适应性神经免疫反应和行为相关的选择性刺激炎症信号的独特调节器。
Immune activity influences reproduction, however, the extent to which mating experience may inversely alter immune pathways is poorly understood. A few studies in humans suggest that mating triggers a circulating immune and hypothalamic-pituitary-adrenal axis response. In male rats, mating experience enhances neuroplasticity and improves cognitive function and affective-like behavior, independent of the physical activity component. Yet, the extent to which mating experience may influence immune responses in the brain remain unexplored. Here, we hypothesized that recent mating experience in male rats increases neuroinflammatory signaling (via lipopolysaccharide [LPS] stimulation, i.p.) and associated sickness behaviors (i.e., food intake, weight loss) relative to sexually-naïve controls. Virgin male rats were exposed to a sexually non-receptive (control) or sexually-receptive female for 30 min for six consecutive days. Immediately following the last mating experience, rats were administered a saline or LPS injection and euthanized four hours later. Mating increased Tnfα responses to LPS in the brain, which positively correlated with LPS-induced weight loss. Mating also increased peripheral corticosterone among saline-treated rats, but this corticosterone response was attenuated in the most proficient copulators (e.g., shortest latencies). Thus, recent mating experience may be a unique modulator of select stimulated inflammatory signals that are relevant to adaptive neuroimmune responses and behavior.