Enterococcal Physiology and Antimicrobial Resistance: The Streetlight Just Got a Little Brighter.
Enterococcal Physiology and Antimicrobial Resistance: The Streetlight Just Got a Little Brighter.
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DOI：
10.1128/mbio.03511-20
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发表时间：
2021-02-23
期刊：
影响因子：
6.4
通讯作者：
Rice LB
中科院分区：
文献类型：
--
作者：
Rice LB
粪肠球菌在生理学和对抗菌剂的敏感性方面与许多其他常见的人类病原体不同。多抗性E.粪肠球菌菌株的表型归因于内在和获得性抗微生物剂抗性决定子的组合。获得性抗性是由于E.粪蝇经常出现在多元文化的环境中，它与不同物种交配的能力，以及在某些谱系中它自己的防御机制的无效。内在抗性是一种复杂的现象，与物种的生理学密切相关。在他们最近在mBio上的研究中，Gilmore和他的同事（M。S.吉尔摩河Salamzade，E. Selleck，N. Bryan等人，mBio 11：e02962-20，2020，https：//doi.org/10.1128/mBio.02962-20）使用功能基因组学探索大肠杆菌的遗传基础。粪便生理学和抗菌素耐药性。虽然他们没有提出许多明确的答案，但他们的工作为新的和富有成效的调查领域指明了道路。
Enterococcus faecalis differs from many other common human pathogens in its physiology and in its susceptibility to antimicrobial agents. Multiresistant E. faecalis strains owe their phenotypes to a combination of intrinsic and acquired antimicrobial resistance determinants. Acquired resistance is due to E. faecalis frequenting multicultural environments, its capacity to mate with different species, and the nullification of its own defense mechanisms in some lineages. Intrinsic resistance is a complex phenomenon that is intimately tied to the physiology of the species. In their recent study in mBio, Gilmore and colleagues (M. S. Gilmore, R. Salamzade, E. Selleck, N. Bryan, et al., mBio 11:e02962-20, 2020, https://doi.org/10.1128/mBio.02962-20) use functional genomics to explore the genetic underpinnings of E. faecalis physiology and antimicrobial resistance. While they do not come up with many definitive answers, their work points the way toward new and fruitful areas of investigation.