Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.
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DOI：
10.1016/j.bmcl.2008.03.079
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发表时间：
2008-05
影响因子：
2.7
通讯作者：
Yuli Xie;Yidong Liu;G. Gong;A. Rinderspacher;S. Deng;Deborah H. Smith;Udo Toebben;Effie Tzilianos;L. Brandén;D. Vidović;Caty Chung;S. Schürer;L. Tautz;D. Landry
中科院分区：
文献类型：
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作者：
Yuli Xie;Yidong Liu;G. Gong;A. Rinderspacher;S. Deng;Deborah H. Smith;Udo Toebben;Effie Tzilianos;L. Brandén;D. Vidović;Caty Chung;S. Schürer;L. Tautz;D. Landry
We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.
