Role of Extracellular Matrix in the Biomechanical Behavior of Pancreatic Tissue
Role of Extracellular Matrix in the Biomechanical Behavior of Pancreatic Tissue
复制标题
DOI：
10.1021/acsbiomaterials.8b00349
复制
发表时间：
2018-05-01
影响因子：
5.8
通讯作者：
Armani, Andrea M.
中科院分区：
文献类型：
--
作者：
Hudnut, Alexa W.;Lash-Rosenberg, Lian;Armani, Andrea M.
将组织的生物力学特性与其功能相关联是一个新兴的研究领域，在诊断学、治疗学和生物学中具有潜在的影响。开发结构-功能模型的一个关键步骤是创建可以将组织结构与其机械行为相关联的方法。作为解决这一挑战的第一步，我们已经使用光纤偏振弹性成像表征了未加工胰腺组织的力学行为。为了将观察到的行为与生理相关的结构特征相关联，使用3D打印设计和制造了一系列架构。使用压缩测试分析3D打印弹性体结构的机械响应，并使用有限元分析进行建模。3D打印结构的生物力学行为和屈曲点用于创建校准曲线，以了解切除的胰腺组织的测量响应。基于建模和仿生结果，胰腺组织的生物力学行为可能是由于IV型胶原网络。
Correlating the biomechanical properties of tissue with its function is an emerging area of research with potential impact in diagnostics, therapeutics, and prognostics. A critical stepping-stone in developing structure-function models is creating methods that can correlate the tissue structure with its mechanical behavior. As an initial step in addressing this challenge, we have characterized the mechanical behavior of unprocessed pancreatic tissue using optical fiber polarimetric elastography. To correlate the observed behavior to physiologically relevant structural features, a series of architectures are designed and fabricated using 3D printing. The mechanical response of the 3D printed elastomeric structures is analyzed using compressive testing and modeled using finite element analysis. The biomechanical behavior and buckling point of the 3D printed structures is used to create a calibration curve to understand the measured response of the resected pancreatic tissue. Based on the modeling and biomimetic results, the biomechanical behavior of pancreatic tissue is likely due to the collagen IV network.