Significance of lncRNA abundance to function
Significance of lncRNA abundance to function
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DOI：
10.1007/s00335-021-09901-4
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发表时间：
2021-08-18
期刊：
影响因子：
2.5
通讯作者：
Lal, Ashish
中科院分区：
文献类型：
--
作者：
Grammatikakis, Ioannis;Lal, Ashish
长链非编码RNA（lncRNA）已成为多种细胞过程的调节因子。尽管与信使RNA（mRNA）相比，绝大多数lncRNA以较低水平表达，但许多lncRNA在细胞稳态和基因表达的调节中起核心作用。随着新一代测序技术的发展，最近的研究表明lncRNA功能的多样性。这种多样性可能是由于它们的作用机制、时空表达和/或丰度的差异，所有这些都可以根据特定的细胞类型或组织而变化。在这里，我们讨论了lncRNA的丰度如何成为一个重要的特征，通常与它们的功能有关，以及为什么定量lncRNA丰度，其在细胞或组织内的局部浓度或在细胞周期进展或环境刺激期间表达水平的动态变化至关重要，以阐明它们的生理作用。
Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse cellular processes. Although the vast majority of lncRNAs are expressed at lower levels compared to messenger RNAs (mRNAs), many lncRNAs play a central role in the regulation of cellular homeostasis and gene expression. With the advancement of next generation sequencing technologies, recent studies illustrate the diversity of lncRNA function. This diversity can be due to differences in their mechanisms of action, spatio-temporal expression, and/or abundance, all of which can vary depending on the particular cell type or tissue. Here, we discuss how the abundance of lncRNAs is an important feature that is often linked to their functions, and why it is crucial to quantitate lncRNA abundance, its local concentration within a cell or a tissue or the dynamic changes in expression levels during cell cycle progression or upon environmental stimuli, to shed light on their physiological roles.