COVID-19 Subclinical Infection and Immunity: A Review.
COVID-19 Subclinical Infection and Immunity: A Review.
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COVID-19-Subclinical感染和免疫力：综述。
DOI：
10.4103/njm.njm_85_21
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Shehu NY
中科院分区：
文献类型：
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作者：
Bartekwa JW;Abene EE;Luka PD;Yilgwan CS;Shehu NY
COVID-19的病原体是一种新型冠状病毒SARS-CoV-2。与其他冠状病毒一样，它通常会引起动物和人类的肠道和呼吸道疾病。COVID-19可能是亚临床的，有症状的，从轻度到重度疾病。呈现谱是多种因素的结果，包括接种量、固有宿主易感性、可能的交叉反应循环抗体。亚临床病毒感染与广泛的社区传播有关，在某些情况下，如脊髓灰质炎，群体免疫。了解2019年亚临床冠状病毒病（COVID-19）的生物学和免疫行为可能有助于寻求疫苗开发以及当前针对COVID-19大流行的控制工作。本文对SARS-CoV-2病毒感染的生物学、发病机制、临床表现等方面的文献进行了综述，重点介绍了我们目前对SARS-CoV-2病毒感染的发病机制、临床表现以及宿主对感染的免疫反应的认识。我们还强调了关于COVID-19亚临床感染的一些研究空白，以及其在疫苗开发和其他预防措施中的潜在应用，以遏制当前的COVID-19大流行。
The aetiologic agent of COVID-19 is a novel coronavirus, SARS-CoV-2. Like other coronaviruses, it generally induces enteric and respiratory diseases in animals and humans. COVID-19 may be subclinical, and symptomatic, ranging from mild–to-severe disease. The spectrum of presentation is the result of several factors ranging from the inoculum size, inherent host susceptibility, possible cross-reacting circulating antibodies. Subclinical viral infections are associated with widespread community transmission and in some cases like Polio, herd immunity. An understanding of the biology and immune behavior in subclinical coronavirus disease 2019 (COVID-19) might be useful in the quest for vaccine development as well as the current control efforts against the COVID-19 pandemic. We carried out a narrative review of the available literature on the biology, etiopathogenesis, clinical manifestation of SARS-CoV-2 viral infection, focusing on our current understanding of the disease mechanisms and its clinical manifestation, and the host immune response to the infection. We also highlighted some of the research gaps regarding subclinical infection in COVID-19 and its potential application for vaccine development and other preventive efforts toward containing the current COVID-19 pandemic.