Tumor endothelial cells express high pentraxin 3 levels
Tumor endothelial cells express high pentraxin 3 levels
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DOI：
10.1111/pin.12474
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发表时间：
2016-12-01
影响因子：
2.2
通讯作者：
Shindoh, Masanobu
中科院分区：
文献类型：
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作者：
Hida, Kyoko;Maishi, Nako;Shindoh, Masanobu
已经描述了肿瘤进展在涉及的信号传导过程方面与炎症和伤口愈合具有许多相似性。在生物学反应中，肿瘤进展和转移所必需的血管生成是常见的标志;因此，肿瘤血管已被认为是抗癌治疗中的重要治疗靶点。我们专注于pentraxin 3（PTX 3），这是癌症相关炎症的标志物，但我们没有发现关于其在肿瘤血管中表达和功能的报道。在此，我们通过免疫组化分析表明PTX 3在小鼠和人肿瘤血管中表达。我们发现，与正常内皮细胞相比，PTX 3在原代小鼠和人肿瘤内皮细胞中上调。我们还发现PTX 3在肿瘤内皮细胞的增殖中起重要作用。这些结果表明，PTX 3是抗血管生成治疗的重要靶点。
It has been described that tumor progression has many similarities to inflammation and wound healing in terms of the signaling processes involved. Among biological responses, angiogenesis, which is necessary for tumor progression and metastasis, is a common hallmark; therefore, tumor blood vessels have been considered as important therapeutic targets in anticancer therapy. We focused on pentraxin 3 (PTX3), which is a marker of cancer-related inflammation, but we found no reports on its expression and function in tumor blood vessels. Here we showed that PTX3 is expressed inmouse and human tumor blood vessels based on immunohistochemical analysis. We found that PTX3 is upregulated in primary mouse and human tumor endothelial cells compared to normal endothelial cells. We also showed that PTX3 plays an important role in the proliferation of the tumor endothelial cells. These results suggest that PTX3 is an important target for antiangiogenic therapy.