Degranulation and decrease in histamine levels of thalamic mast cells coincides with corticosterone secretion induced by compound 48/80.
Degranulation and decrease in histamine levels of thalamic mast cells coincides with corticosterone secretion induced by compound 48/80.
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DOI：
10.1007/bf01674391
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发表时间：
1995-04-01
期刊：
影响因子：
--
通讯作者：
Bugajski, J
中科院分区：
文献类型：
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作者：
Bugajski, A J;Chlap, Z;Bugajski, J
肥大细胞（MC）合成并分泌许多强有力的介质，如组胺（HA）、5-羟色胺和肾上腺素（PGs），已知它们对血管和神经组织具有显著的生理作用。在大鼠脑中，HA位于至少两种不同的细胞类型中：神经元和MC [1]。这两个资源库中每一个的数量重要性仍有争议。虽然有大量的证据表明神经元HA是中枢神经系统中的神经递质，但是由存在于脑结构中的MC的HA执行的特定功能仍然是推测性的。化合物48/80是一种标准MC脱粒剂，侧脑室（icv）给药的HA抑制剂降低了MC的数量和粗核部分的HA含量，但不降低神经元部分的HA [2]。
Mast cells (MC) synthesize and secrete numerous powerful mediators such as histamine (HA), serotonin and prostaglandins (PGs), which are known to have significant physiological effects on vascular and neuronal tissues.In the rat brain, HA is located in at least two different cell types: neurons and MC [1]. The quantitative importance of each of these two pools is still controversial. While there is a large body of evidence suggesting that neuronal HA is a neurotransmitter in the central nervous system, the specific functions carried out by HA of the MC present in brain structures remain speculative. Compound 48/80 a standard MC degranulating agent and HA releaser administered intracerebroventricularly (icv) decreased both the number of MC and the HA content of the crude nuclear fraction but not HA of the neuronal fraction [2].