Overexpression of Fas and FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes.
Overexpression of Fas and FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes.
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Fas和FasL的过表达通过促进淋巴细胞凋亡与实验性重症急性胰腺炎的感染并发症和严重程度相关
DOI：
10.1007/s10753-014-9847-8
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发表时间：
2014-08
期刊：
影响因子：
5.1
通讯作者：
Sooranna, Suren R.
中科院分区：
文献类型：
--
作者：
Liao Pinhu;Qin, Yueqiu;Xiong, Bin;You, Yanwu;Li, Jun;Sooranna, Suren R.
本研究探讨了实验性重症急性胰腺炎（SAP）小鼠淋巴细胞Fas、Fas配体（FasL）表达及凋亡与免疫反应和感染并发症的关系。40只雄性Balb/c小鼠随机分为对照组、轻度急性胰腺炎（MAP）组和重度急性胰腺炎（SAP）组。SAP患者脾淋巴细胞Fas/FasL mRNA和蛋白表达明显增强（P< 0.01）。这些细胞的凋亡导致该组中循环淋巴细胞的耗竭（p< 0.05）。观察到SAP感染并发症组的进一步显著变化。Fas/FasL表达与SAP小鼠淋巴细胞凋亡呈正相关，与CD 4+、CD 19+淋巴细胞及CD 4 +/CD 8+比值呈负相关（p< 0.01）。结果提示Fas/FasL的过度表达可能通过促进淋巴细胞凋亡而与实验性重症急性胰腺炎的感染并发症和严重程度相关。
This study investigated the relationship of Fas and Fas ligand (FasL) expression and apoptosis of lymphocytes in relation to the pathogenic immune response and infectious complications observed in experimental severe acute pancreatitis in mice. Forty male Balb/c mice were randomly divided into control, mild (MAP), and severe acute pancreatitis (SAP) groups. Overexpression of Fas/FasL messenger ribonucleic acid (mRNA) and protein was observed in spleen-derived lymphocytes in SAP (p< 0.01). Apoptosis of these resulted in a depletion of circulating lymphocytes in this group (p< 0.05). A further significant change in the SAP group with infectious complications was observed. A positive relationship was found between the Fas/FasL expression and lymphocyte apoptosis, and negative relationships were observed between Fas/FasL expression and CD4+and CD19+lymphocytes and the CD4+/CD8+ratio in SAP mice (p< 0.01). The results suggest that the overexpression of Fas/FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes.
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DOI：
10.1073/pnas.96.25.14541
发表时间：
1999-12-07
影响因子：
11.1
作者：
Hotchkiss, RS;Tinsley, KW;Karl, IE
通讯作者：
Karl, IE
影响因子：
6
作者：
Moriez, R;Salvador-Cartier, C;Bueno, L
通讯作者：
Bueno, L
影响因子：
4.3
作者：
Dang, Sheng-Chun;Zhang, Jian-Xin;Zhu, Bei
通讯作者：
Zhu, Bei
影响因子：
2.2
作者：
Gallagher, SF;Yang, J;Murr, MM
通讯作者：
Murr, MM
DOI：
10.1152/ajpgi.00016.2006
发表时间：
2006-11-01
影响因子：
4.5
作者：
Hartwig, Werner;Klafs, Martina;Werner, Jens
通讯作者：
Werner, Jens