Transitions, Risks, and Actions in Coronary Events--Center for Outcomes Research and Education (TRACE-CORE): design and rationale.
Transitions, Risks, and Actions in Coronary Events--Center for Outcomes Research and Education (TRACE-CORE): design and rationale.
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DOI：
10.1161/circoutcomes.112.965418
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发表时间：
2012-09-01
期刊：
影响因子：
--
通讯作者：
TRACE-CORE Investigators
中科院分区：
文献类型：
--
作者：
Waring ME;McManus RH;Saczynski JS;Anatchkova MD;McManus DD;Devereaux RS;Goldberg RJ;Allison JJ;Kiefe CI;TRACE-CORE Investigators
心血管疾病继续导致显著的发病率、死亡率和生活质量受损，由于未充分利用现有证据，未实现健康收益。冠状动脉事件转归研究和教育中心（TRACE-CORE）的转变、风险和行动旨在通过检查从医院到社区的转变质量的决定因素和转归，并通过量化与生活质量下降、再住院和死亡率相关的潜在可改变特征的影响，来推进急性冠状动脉综合征（ACS）的科学。TRACE-CORE由ACS住院患者的纵向多种族队列、两个研究项目和早期研究者核心的发展组成。我们目前正在美国东北部和东南部的6家医院招募2,500名因ACS住院的成年人。我们将通过病历摘要和6名患者访谈对这些患者进行住院后24个月的随访，重点关注生活质量、心脏事件、再住院、死亡率以及医学、行为和心理社会特征。过渡项目研究了患者从医院到社区过渡的质量结果的决定因素和差异。关注潜在的可修改因素，行动评分项目将开发和验证行动评分，以预测复发性心脏事件，死亡和生活质量，描述这些评分的纵向变化，并根据这些评分为患者和提供者制定行动仪表板。在TRACE-CORE中，观察性研究的合理方法学原则与结果和有效性研究方法趋同。我们希望我们的数据，研究基础设施和研究项目将为新型二级预防方法的发展提供信息，并为CVD结果研究人员的职业生涯提供支持。
Cardiovascular disease continues to cause significant morbidity, mortality, and impaired quality of life, with unrealized health gains from the underuse of available evidence. The Transitions, Risks, and Actions in Coronary Events Center for Outcomes Research and Education (TRACE-CORE) aims to advance the science of acute coronary syndromes (ACS) by examining the determinants and outcomes of the quality of the transition from the hospital to the community and by quantifying the impact of potentially-modifiable characteristics associated with decreased quality of life, rehospitalization, and mortality. TRACE-CORE is composed of a longitudinal multi-racial cohort of patients hospitalized with ACS, two research projects, and development of a nucleus of early stage investigators. We are currently enrolling 2,500 adults hospitalized for ACS at 6 hospitals in the northeastern and southeastern United States. We will follow these patients for 24 months after hospitalization through medical record abstraction and six patient interviews focusing on quality of life, cardiac events, rehospitalizations, mortality, and medical, behavioral, and psychosocial characteristics. The Transitions Project studies determinants of and disparities in outcomes of the quality of patients’ transition from the hospital to the community. Focusing on potentially modifiable factors, the Action Scores Project will develop and validate action scores to predict recurrent cardiac events, death, and quality of life, describe longitudinal variation in these scores, and develop a dashboard for patient and provider action based on these scores. In TRACE-CORE, sound methodologic principles of observational studies converge with outcomes and effectiveness research approaches. We expect that our data, research infrastructure, and research projects will inform the development of novel secondary prevention approaches and underpin the careers of CVD outcomes researchers.