SUBSTRATE AND ENDOCRINE RESPONSES DURING EXERCISE AT SELECTED STAGES OF PREGNANCY
SUBSTRATE AND ENDOCRINE RESPONSES DURING EXERCISE AT SELECTED STAGES OF PREGNANCY
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DOI：
10.1152/jappl.1992.73.1.134
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发表时间：
1992-07-01
影响因子：
3.3
通讯作者：
BERESFORD, P
中科院分区：
文献类型：
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作者：
BONEN, A;CAMPAGNA, P;BERESFORD, P
为了确定怀孕和运动的伴随效应是否产生了与单独运动时预期的不同的底物和内分泌模式，我们比较了非怀孕妇女(NP；n=7)和怀孕第二个月(TR2；n=6)和妊娠晚期(TR3；n=8)的非怀孕妇女(NP；n=7)和怀孕第二个月(TR2；n=6)和妊娠晚期(TR3；n=8)在130-140次/分钟自行车测功机运动前、中、后30分钟心率的变化。总体而言，所有底物和激素浓度都随着运动而增加(P<；0.05)，除了胰岛素下降(P<；0.05)和HCG没有变化(P=0.08)。由于妊娠的不同阶段，不同组之间选定的激素浓度(P、雌三醇、绒毛膜促性腺激素和HPL)在静息状态下已经存在差异。安静时各组间胰岛素和去甲肾上腺素水平也有差异(P<；0.05)。对运动的显著不同反应(即，X组时间交互作用)如下。NP与TR2：P、雌三醇、HCG、HPL、EP和NE(P<；0.05)；NP与TR3：葡萄糖、EP和NE(P<；0.05)；TR2与TR3：乳酸、EP和NE(P<；0.05)。然而，特别值得注意的是，1)底物和激素的变化是相当短暂的；在大多数情况下，运动前的浓度在运动后30分钟内恢复，2)胎儿心率没有变化(P>；0.05)，尽管运动诱导的孕妇心率增加(P<；0.05)，3)TR2和TR3组的妇女经历了25%和32%的血糖下降，显著高于对照组的16%(P<；0.05)。因此，尽管运动不会引起孕妇异常的内分泌反应，但TR2和TR3在运动过程中血糖的大幅下降可能需要谨慎。
To determine whether the concomitant effects of pregnancy and exercise yield substrate and endocrine patterns different from those expected during exercise alone, we compared the responses of glucose, lactate, free fatty acids, insulin, epinephrine (EP), norepinephrine (NE), human chorionic gonadotropin (HCG), human placental lactogen (HPL), estriol, and progesterone (P) in nonpregnant women (NP; n = 7) and pregnant women in the second (TR2; n = 6) and third trimester (TR3; n = 8) of pregnancy, before, during, and after 30 min of bicycle ergometer exercise at heart rates of 130-140 beats/min. In general, all substrates and hormone concentrations increased with exercise (P < 0.05), except insulin, which decreased (P < 0.05), and HCG, which did not change (P = 0.08). Differences in selected hormone concentrations (P, estriol, HCG, and HPL) among groups were already present at rest because of the different stages of pregnancy. Differences among groups at rest were also found in insulin and NE (P < 0.05). Significantly different responses to exercise (i.e., group X time interactions) were as follows. NP vs. TR2: P, estriol, HCG, HPL, EP, and NE (P < 0.05); NP vs. TR3: glucose, EP, and NE (P < 0.05); TR2 vs. TR3: lactate, EP, and NE (P < 0.05). It was especially noteworthy that 1) the substrate and hormonal changes were, however, quite transient; in most instances, preexercise concentrations were reestablished within 30 min after exercise, 2) no changes in fetal heart rates occurred (P > 0.05) despite the increments in exercise-induced maternal heart rates (P < 0.05), and 3) the women in TR2 and TR3 experienced glucose decrements of 25 and 32% that were significantly greater (P < 0.05) than the 16% decrement in the control group. Therefore, although exercise does not provoke anomalous endocrine responses in pregnant women, the large glucose decrease during exercise in TR2 and TR3 may require caution.