Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects.
Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects.
复制标题
DOI：
10.2147/opth.s14573
复制
发表时间：
2010-12-06
期刊：
影响因子：
--
通讯作者：
Mimura O
中科院分区：
文献类型：
--
作者：
Kurimoto T;Oono S;Oku H;Tagami Y;Kashimoto R;Takata M;Okamoto N;Ikeda T;Mimura O
本文的目的是研究经角膜电刺激（TES）对健康人绒毛膜视网膜血流的影响。采用激光散斑血流成像技术测量10名健康受试者在TES前后的绒毛膜视网膜血流，并用正方形模糊率（SBR）表示。测定TES前后及TES后0.5、1、1.5、2、2.5、3、24、40 h视盘边缘、视盘与黄斑中间点、黄斑区域三个不同区域的绒毛膜视网膜血流量。受刺激眼睛的SBR是相对于另一只眼睛的值来表示的。平均标准化模糊比计算为标准化SBR与基线SBR的比值。每次测量SBR后，测定眼内压（IOP）、血压（BP）和脉搏率（PR）的变化。眼灌注压（OPP）由BP和IOP计算。视盘的平均标准化模糊比在整个实验过程中没有显著变化。而视盘与黄斑中间及黄斑区域的平均标准化模糊比，TES治疗后3、24 h均显著高于假刺激后（P < 0.05, P < 0.01）。在任何时候，平均BP、PR、IOP和OPP与预估值没有显著差异。TES能增加正常受试者的绒毛膜视网膜血流量，对全身血液循环和眼压的影响最小。绒毛膜视网膜血流量的增加可能是TES对缺血性视网膜疾病的有益作用之一。
The aim of this article is to investigate the effect of transcorneal electrical stimulation (TES) on chorioretinal blood flow in healthy human subjects. The chorioretinal blood flow of 10 healthy subjects was measured before and after TES by laser speckle flowgraphy and expressed as the square blur rate (SBR). The chorioretinal blood flow was determined before and immediately after TES and 0.5, 1, 1.5, 2, 2.5, 3, 24, and 40 h after TES in three different areas: the margin of the optic disc, a point located midway between the optic disc and macula, and the macula area. The SBR of the stimulated eye is expressed relative to the value of the fellow eye. The mean standardized blur ratio was calculated as the ratio of the standardized SBR to the baseline SBR. The changes of intraocular pressure (IOP), blood pressure (BP), and pulse rate (PR) were determined after each measurement of the SBR. The ocular perfusion pressure (OPP) was calculated from BP and IOP. The mean standardized blur ratio at the optic disc did not change significantly throughout the course of the experiment. However, the mean standardized blur ratio midway between the optic disc and macula and at the macula area were significantly higher after TES than that after sham stimulation at 3 and 24 h (P < 0.05, P < 0.01, respectively). At all times, the mean BP, PR, IOP, and OPP were not significantly different from the prestimulation values. TES increases the chorioretinal blood flow in normal subjects with minimal effects on the systemic blood circulation and the IOP. The increase in chorioretinal blood flow may be one of the beneficial effects that TES has on ischemic retinal diseases.