Molecular imaging with Pittsburgh compound B confirmed at autopsy - A case report
Molecular imaging with Pittsburgh compound B confirmed at autopsy - A case report
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DOI：
10.1001/archneur.64.3.431
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发表时间：
2007-03-01
影响因子：
--
通讯作者：
Growdon, John H.
中科院分区：
文献类型：
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作者：
Bacskai, Brian J.;Frosch, Matthew P.;Growdon, John H.
目的：探讨生活中摄取匹兹堡化合物B(PIB)与尸检组织中β-淀粉样蛋白(Aβ)的相关性。患者：76岁，临床诊断为路易体痴呆患者，行F-18和PIB正电子发射断层扫描。介入：在PIB扫描后3个月进行尸检。结果：尸检证实了临床诊断；此外，还有严重的脑淀粉样血管病变，只有中等数量的Aβ实质斑块。生化指标显示Aβ水平与局部PIB结合呈正相关。结论：这份报告证实了PIB在活着的患者中检测到Aβ，并表明淀粉样蛋白沉积为脑淀粉样血管病变可能是主要的信号来源。
Objective: To determine the correspondence between uptake of Pittsburgh Compound B (PiB) in life and measures of beta-amyloid (A beta) in postmortem tissue analysis.Patient: A 76-year-old man with a clinical diagnosis of dementia with Lewy bodies underwent fluorodeoxyglucose F-18 and PiB positron emission tomographic brain scans. Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake.Intervention: Autopsy was performed 3 months after the PiB scan.Results: Autopsy confirmed the clinical diagnosis; in addition, there was severe cerebral amyloid angiopathy and only moderate numbers of parenchymal A beta plaques. Biochemical measures revealed a positive correlation between A beta levels and regional PiB binding.Conclusion: This report confirms that PiB detects A beta in the living patient and demonstrates that amyloid deposited as cerebral amyloid angiopathy can be the dominant source of signal.