Radiopharmaceuticals for imaging and therapy.
Radiopharmaceuticals for imaging and therapy.
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DOI：
10.1039/c1dt90067f
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发表时间：
2011-05
影响因子：
4
通讯作者：
S. Faulkner;N. Long
中科院分区：
文献类型：
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作者：
S. Faulkner;N. Long
放射性药物已经为疾病的诊断和治疗做出了巨大贡献。该领域的快速发展仍在继续，具有重要的新方法来靶向，生物缀合和生物动力学控制，以及通过新放射性同位素的应用和纯化，新实验技术的开发和放射性同位素在多模态成像中的应用。现在似乎是时候强调和审查这些发展，并在一个单一的问题，以更广泛的社会无机化学家。在放射性药物化学的主题问题上，我们的目标是突出该领域领先专家的贡献，说明这些新发展的范围并详细分析其潜力。这期杂志包含了一些观点文章和论文，它们概述并扩展了该领域当前发展的一些关键主题。利用放射性同位素的成像方式的发展使临床科学家能够了解和诊断疾病的进展。早期的断层扫描探头主要用于血流和血池成像，但其范围已扩展到真正的功能成像。在临床中，18-FDG的使用现在很普遍，而具有双功能螯合剂的金属络合物已被证明靶向细胞受体和摄取途径。
Radiopharmaceuticals have already made an enormous contribution to the diagnosis and therapy of disease. Rapid development of the field continues, with important new approaches to targeting, bioconjugation and control of biological kinetics as well as through the application and purification of new radioisotopes, the development of new experimental techniques and the application of radioisotopes in multimodal imaging. The time seems right to highlight and review these developments, and to present them in a single issue to the wider community of inorganic chemists. With this themed issue on radiopharmaceutical chemistry, we are aiming to highlight contributions from leading experts in the field, illustrating the scope of these new developments and analysing their potential in detail. This issue contains a mix of perspective articles and papers, which outline and expand upon some of the key themes in the current development of the field.The development of imaging modalities that make use of radioisotopes has allowed clinical scientists to understand and diagnose the progress of disease. Early tomographic probes focused upon imaging blood flow and blood pool, but their scope has been extended to truly functional imaging. In the clinic, the use of 18-FDG is now widespread, while metallic complexes with bifunctional chelating agents have been shown to target cell receptors and uptake pathways.