Electrospun nanofibers for neural tissue engineering
Electrospun nanofibers for neural tissue engineering
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DOI：
10.1039/b9nr00243j
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发表时间：
2010-01-01
期刊：
影响因子：
6.7
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Xie, Jingwei;MacEwan, Matthew R.;Xia, Younan
静电纺丝法制备的生物可降解纳米纤维是一类新的支持神经再生的支架材料。我们开始与一个简短的讨论，对静电纺丝的纳米纤维和方法，用于控制的结构，孔隙率，和取向的静电纺丝纳米纤维。该方法包括控制纳米纤维的纳米级形态和微米级排列，以及制造宏观尺度的三维管状结构。然后，我们强调最近的研究，利用静电纺丝纳米纤维操纵相关的神经组织再生，包括干细胞分化，指导神经突起延伸，周围神经损伤治疗的生物过程。这篇专题文章的主要目的是为研究新型纳米纤维支架上神经突生长机制的方法提供有价值的见解，并优化用于修复周围神经损伤的纳米纤维支架和导管。
Biodegradable nanofibers produced by electrospinning represent a new class of promising scaffolds to support nerve regeneration. We begin with a brief discussion on the electrospinning of nanofibers and methods for controlling the structure, porosity, and alignment of the electrospun nanofibers. The methods include control of the nanoscale morphology and microscale alignment of the nanofibers, as well as the fabrication of macroscale, three-dimensional tubular structures. We then highlight recent studies that utilize electrospun nanofibers to manipulate biological processes relevant to nervous tissue regeneration, including stem cell differentiation, guidance of neurite extension, and peripheral nerve injury treatments. The main objective of this feature article is to provide valuable insights into methods for investigating the mechanisms of neurite growth on novel nanofibrous scaffolds and optimization of the nanofiber scaffolds and conduits for repairing peripheral nerve injuries.