Sex differences in conditioned nicotine reward are age-specific.
Sex differences in conditioned nicotine reward are age-specific.
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DOI：
10.1016/j.pbb.2015.02.019
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Izenwasser S
中科院分区：
文献类型：
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作者：
Lenoir M;Starosciak AK;Ledon J;Booth C;Zakharova E;Wade D;Vignoli B;Izenwasser S
女性占所有吸烟者的一半，许多研究表明，成年男性和女性在维持吸烟的因素方面存在差异，但关于青春期尼古丁奖励的性别差异的信息有限。有限的研究表明，青春期雄性大鼠比成年大鼠自我给予更多的尼古丁，这表明青春期给药会导致与成年期不同的行为影响。在本研究中，雄性大鼠对较低剂量的尼古丁比雌性大鼠产生了显着的条件性位置偏好（CPP），无论年龄如何。此外，青少年比成年人更敏感。在雌性大鼠中，青少年表现出比成年雌性更大的CPP。在雄性动物中，CPP的大小不随年龄而变化，但青少年的CPP剂量低于成人。不同年龄和性别的大鼠对尼古丁的反应中，丘脑核和尾壳核的烟碱乙酰胆碱能受体结合也存在差异。这些发现表明，在制定改善戒烟治疗的策略时，有必要考虑尼古丁等药物的性别和年龄特异性影响。
Women constitute half of all smokers and many studies suggest that adult males and females differ in factors that maintain tobacco smoking, yet there is limited information about sex differences in nicotine reward during adolescence. Limited studies suggest that adolescent male rats self-administer more nicotine than adults, suggesting that drug administration during adolescence leads to different behavioral effects than during adulthood. In the present study, male rats developed a significant conditioned place preference (CPP) to lower doses of nicotine than females, regardless of age. In addition, adolescents were more sensitive than adults. In female rats, adolescents exhibited a CPP of greater magnitude than adult females. In males, the magnitude of the CPP did not differ as a function of age, but adolescents exhibited CPP to lower doses than adults. There also were differences in nicotinic acetylcholinergic receptor binding in nucleus accumbens and caudate putamen in response to nicotine across age and sex. These findings suggest that it is necessary to consider sex- and age-specific effects of drugs such as nicotine when developing strategies for improving smoking cessation treatments.