Delayed effects of radiation on the human central nervous system
Delayed effects of radiation on the human central nervous system
复制标题
辐射对人体中枢神经系统的延迟影响
作者：
P. Lampert;R. Davis
文摘：本文报告两例人体中枢神经系统辐射迟发性效应。其中一例显示了罕见的早期延迟反应，发生在辐射后大约三个月。这些病变最类似于急性多发性硬化症的斑块，与退行性血管变化无关。这名患者可能代表了肖尔茨在狗身上报告的早期延迟反应的极端。有临床证据表明，这种类型的某种程度的损害发生的频率比人们怀疑的要高。另1例为晚期延迟反应，有明显的血管退行性改变，脑白质严重破坏，皮质受累较少。这位病人是一个有文献记载的辐射迟发效应的极端例子，与病例1中的病人对比。在照射的皮质中出现肥大的神经元是一个新的和无法解释的发现。(作者)
Abstract : Two cases of delayed effects of radiation on the central nervous system of man are reported. One demonstrates the rare early delayed reaction which occurs approximately three months after radiation. The lesions resemble most closely the plaques of acute multiple sclerosis and are not associated with degenerative vascular changes. This patient probably represents an extreme of the early delayed reaction reported by Scholz in dogs. There is clinical evidence suggesting that some degree of damage of this type occurs more frequently than has been suspected. The other patient had the late delayed reaction in which there are marked degenerative vascular alternations and severe destruction of the white matter with little cortical involvement. This patient is an extreme example of the well-documented late delayed effects of radiation and is presented for contrast with the patient in case 1. The presence of hypertrophic neurons in the irradiated cortex is a new and unexplained finding. (Author)