INTRAOCULAR MELANOMA, DIABETES, AND TURNERS SYNDROME - PRESENTATION WITH PROPTOSIS
INTRAOCULAR MELANOMA, DIABETES, AND TURNERS SYNDROME - PRESENTATION WITH PROPTOSIS
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DOI：
10.1136/bjo.65.7.460
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发表时间：
1981-01-01
影响因子：
4.1
通讯作者：
CHENG, H
中科院分区：
文献类型：
--
作者：
BUCKLEY, CA;CHENG, H
一名患有特纳综合征且未经治疗的糖尿病患者出现失明、疼痛、青光眼和进行性单侧突眼。尽管计算机断层扫描 [CT] 扫描未能显示推测的脉络膜黑色素瘤眼后扩展的证据，但临床特征提示眼外扩展，因此考虑进行眼眶摘除术。对摘除眼的组织学检查显示恶性黑色素瘤的存在，显示没有眼外扩展，眼后结缔组织的组织学显示仅出血和成纤维细胞活性。还有另外 3 例报告的恶性黑色素瘤病例，表现为突眼，无眼外延伸，因此，当临床上认为有必要进行摘除但 CT 扫描无法显示肿瘤直接扩散时，需要格外小心。
A patient with Turner''s syndrome and untreated diabetes mellitus presented with a blind, painful, glaucomatous eye and progressive unilateral proptosis. Although a computerized tomographic [CT] scan failed to show evidence of a retroocular extension of the presumed choroidal melanoma, the clinical features were so suggestive of extraocular extension that an orbital exenteration was considered. Examination of the enucleated eye for histological confirmation of the presence of malignant melanoma showed no extraocular extension, and histology of the retroocular connective tissue revealed only hemorrhage and fibroblastic activity. There are 3 other reported cases of malignant melanoma presenting as proptosis without extraocular extension, so that extreme caution is required when exenteration is deemed necessary on clinical grounds but where CT scanning fails to reveal direct tumor spread.